HUMAN ANATOMY W/ACCESS
6th Edition
ISBN: 9781260929539
Author: SALADIN
Publisher: MCG
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Chapter 21, Problem 6WWWTS
Summary Introduction
To determine:
If the given statement is true or false should be determined.
Introduction:
Blood capillaries are made up of only an endothelium and basal lamina. They have thin walls having a width of 0.2-0.4 μm. They have a diameter of about 5 μm at the proximal end and of 9 μm at the distal end.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 21 Solutions
HUMAN ANATOMY W/ACCESS
Ch. 21.1 - Why would venous valves be unnecessary in the...Ch. 21.1 - Prob. 1BYGOCh. 21.1 - Answer the following questions to test your...Ch. 21.1 - Answer the following questions to test your...Ch. 21.1 - Prob. 4BYGOCh. 21.1 - Prob. 5BYGOCh. 21.1 - Prob. 6BYGOCh. 21.2 - Prob. 7BYGOCh. 21.2 - Prob. 8BYGOCh. 21.3 - Prob. 1AWYK
Ch. 21.3 - Prob. 9BYGOCh. 21.3 - Prob. 10BYGOCh. 21.3 - Prob. 11BYGOCh. 21.3 - Prob. 12BYGOCh. 21.3 - Prob. 13BYGOCh. 21.4 - Prob. 1AWYKCh. 21.4 - Prob. 14BYGOCh. 21.4 - Prob. 15BYGOCh. 21.4 - Prob. 16BYGOCh. 21.4 - Prob. 17BYGOCh. 21.4 - From the preceding discussion of arteries veins of...Ch. 21.5 - Prob. 18BYGOCh. 21.5 - Prob. 19BYGOCh. 21.5 - Prob. 20BYGOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.1.3AYLOCh. 21 - Prob. 21.1.4AYLOCh. 21 - Prob. 21.1.5AYLOCh. 21 - Prob. 21.1.6AYLOCh. 21 - Prob. 21.1.7AYLOCh. 21 - Prob. 21.1.8AYLOCh. 21 - Prob. 21.1.9AYLOCh. 21 - Prob. 21.1.10AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.1.12AYLOCh. 21 - Prob. 21.1.13AYLOCh. 21 - Prob. 21.2.1AYLOCh. 21 - Prob. 21.2.2AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.3.2AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.3.6AYLOCh. 21 - Prob. 21.3.7AYLOCh. 21 - Prob. 21.3.8AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.3.10AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.3.13AYLOCh. 21 - Prob. 21.3.14AYLOCh. 21 - Prob. 21.3.15AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.3.18AYLOCh. 21 - Prob. 21.3.19AYLOCh. 21 - Prob. 21.3.20AYLOCh. 21 - Prob. 21.4.1AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.4.3AYLOCh. 21 - Prob. 21.4.4AYLOCh. 21 - Prob. 21.4.5AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.5.2AYLOCh. 21 - To test your knowledge, discuss the following...Ch. 21 - Prob. 21.5.4AYLOCh. 21 - Prob. 21.5.5AYLOCh. 21 - Prob. 1TYRCh. 21 - Prob. 2TYRCh. 21 - Prob. 3TYRCh. 21 - A circulatory pathway in which the blood flows...Ch. 21 - Prob. 5TYRCh. 21 - Prob. 6TYRCh. 21 - Prob. 7TYRCh. 21 - Prob. 8TYRCh. 21 - Prob. 9TYRCh. 21 - Prob. 10TYRCh. 21 - Prob. 11TYRCh. 21 - Prob. 12TYRCh. 21 - Prob. 13TYRCh. 21 - Prob. 14TYRCh. 21 - Prob. 15TYRCh. 21 - Prob. 16TYRCh. 21 - Prob. 17TYRCh. 21 - Prob. 18TYRCh. 21 - Prob. 19TYRCh. 21 - Prob. 20TYRCh. 21 - Prob. 1BYMVCh. 21 - Prob. 2BYMVCh. 21 - Prob. 3BYMVCh. 21 - Prob. 4BYMVCh. 21 - Prob. 5BYMVCh. 21 - Prob. 6BYMVCh. 21 - Prob. 7BYMVCh. 21 - Prob. 8BYMVCh. 21 - Prob. 9BYMVCh. 21 - Prob. 10BYMVCh. 21 - Prob. 1WWWTSCh. 21 - Prob. 2WWWTSCh. 21 - Prob. 3WWWTSCh. 21 - Prob. 4WWWTSCh. 21 - Prob. 5WWWTSCh. 21 - Prob. 6WWWTSCh. 21 - Prob. 7WWWTSCh. 21 - Prob. 8WWWTSCh. 21 - Prob. 9WWWTSCh. 21 - Prob. 10WWWTSCh. 21 - Prob. 1TYCCh. 21 - Prob. 2TYCCh. 21 - What differences would you expect between a sample...Ch. 21 - Prob. 4TYCCh. 21 - Prob. 5TYC
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