2 SEM CARDLESS ACC W/RAVEN TEXT
12th Edition
ISBN: 9781265810467
Author: Raven
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 21, Problem 5S
The ancestor of horses was a small, many-toed animal that lived in forests, whereas today’s horses are large animals with a single hoof that live on open plains. A series of intermediate fossils illustrate how this transition has occurred, and for this reason, many old treatments of horse evolution portrayed it as a steady increase through time in body size accompanied by a steady decrease in toe number. Why is this interpretation incorrect?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 21 Solutions
2 SEM CARDLESS ACC W/RAVEN TEXT
Ch. 21.1 - Prob. 1LOCh. 21.1 - Prob. 2LOCh. 21.2 - Prob. 1LOCh. 21.2 - Distinguish between demonstrating that evolution...Ch. 21.3 - Contrast the processes of artificial and natural...Ch. 21.3 - Prob. 2LOCh. 21.4 - Prob. 1LOCh. 21.4 - Prob. 2LOCh. 21.4 - Prob. 3LOCh. 21.5 - Explain the evolutionary significance of...
Ch. 21.5 - Prob. 2LOCh. 21.6 - Prob. 1LOCh. 21.6 - Prob. 2LOCh. 21.7 - Characterize the criticisms of evolutionary theory...Ch. 21.7 - Prob. 2LOCh. 21 - Suppose that a male with a beak depth of 10 mm...Ch. 21 - Prob. 1IQCh. 21 - Prob. 2IQCh. 21 - Prob. 3IQCh. 21 - Why might the evolutionary line leading to...Ch. 21 - Artificial selection is different from natural...Ch. 21 - Gaps in the fossil record a. demonstrate our...Ch. 21 - The evolution of modern horses (Equus) is best...Ch. 21 - Homologous structures a. are structures in two or...Ch. 21 - Convergent evolution a. is an example of...Ch. 21 - Prob. 6UCh. 21 - The possession of fine fur in 5-month human...Ch. 21 - In Darwins finches, a. occurrence of wet and dry...Ch. 21 - Prob. 2ACh. 21 - Convergent evolution is often seen among species...Ch. 21 - What conditions are necessary for evolution by...Ch. 21 - Explain how data shown in figure 21.2a and b...Ch. 21 - Prob. 3SCh. 21 - Refer to figure 21.5, artificial selection in the...Ch. 21 - The ancestor of horses was a small, many-toed...
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