Biology: Concepts and Investigations
5th Edition
ISBN: 9781260259049
Author: Hoefnagels
Publisher: MCG
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Textbook Question
Chapter 21, Problem 3PIT
3. Draw a concept map that summarizes the chordates, including both invertebrates and vertebrates.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 21 Solutions
Biology: Concepts and Investigations
Ch. 21.1 - Prob. 1MCCh. 21.1 - Prob. 2MCCh. 21.1 - Prob. 3MCCh. 21.1 - Prob. 4MCCh. 21.1 - Prob. 5MCCh. 21.1 - What advantages does segmentation confer?Ch. 21.1 - Prob. 7MCCh. 21.2 - Prob. 1MCCh. 21.2 - Prob. 2MCCh. 21.2 - Prob. 3MC
Ch. 21.2 - Prob. 4MCCh. 21.3 - Prob. 1MCCh. 21.3 - Prob. 2MCCh. 21.3 - Prob. 3MCCh. 21.3 - Prob. 4MCCh. 21.4 - Prob. 1MCCh. 21.4 - Prob. 2MCCh. 21.4 - Prob. 3MCCh. 21.4 - Prob. 4MCCh. 21.5 - Prob. 1MCCh. 21.5 - Prob. 2MCCh. 21.5 - Prob. 3MCCh. 21.5 - Prob. 4MCCh. 21.5 - Prob. 5MCCh. 21.6 - What defining feature arose in the annelid lineage...Ch. 21.6 - Prob. 2MCCh. 21.6 - Prob. 3MCCh. 21.6 - Prob. 4MCCh. 21.6 - Prob. 5MCCh. 21.7 - Prob. 1MCCh. 21.7 - Prob. 2MCCh. 21.7 - Prob. 3MCCh. 21.7 - Prob. 4MCCh. 21.7 - Prob. 5MCCh. 21.8 - Prob. 1MCCh. 21.8 - Prob. 2MCCh. 21.8 - Prob. 3MCCh. 21.8 - Prob. 4MCCh. 21.8 - What are the advantages and disadvantages of an...Ch. 21.8 - Prob. 6MCCh. 21.8 - Prob. 7MCCh. 21.8 - Prob. 8MCCh. 21.9 - Prob. 1MCCh. 21.9 - Prob. 2MCCh. 21.9 - What are some examples of echinoderms?Ch. 21.9 - Prob. 4MCCh. 21.10 - What are four key defining characteristics of...Ch. 21.10 - Prob. 2MCCh. 21.10 - Prob. 3MCCh. 21.10 - Prob. 4MCCh. 21.10 - Differentiate between an ectotherm and an...Ch. 21.10 - How does the number of heart chambers affect the...Ch. 21.11 - Compare and contrast the features of tunicates and...Ch. 21.11 - Prob. 2MCCh. 21.11 - Prob. 3MCCh. 21.12 - Prob. 1MCCh. 21.12 - Prob. 2MCCh. 21.13 - Prob. 1MCCh. 21.13 - Prob. 2MCCh. 21.13 - Prob. 3MCCh. 21.14 - Prob. 1MCCh. 21.14 - Prob. 2MCCh. 21.14 - What features distinguish the three orders of...Ch. 21.15 - Prob. 1MCCh. 21.15 - Prob. 2MCCh. 21.15 - Prob. 3MCCh. 21.15 - Prob. 4MCCh. 21.15 - Prob. 5MCCh. 21.15 - Prob. 6MCCh. 21.16 - Prob. 1MCCh. 21.16 - Prob. 2MCCh. 21.16 - Prob. 3MCCh. 21.17 - Prob. 1MCCh. 21.17 - Prob. 2MCCh. 21 - Following gastrulation, the cells that have folded...Ch. 21 - Prob. 2MCQCh. 21 - How is the body structure of an annelid different...Ch. 21 - Prob. 4MCQCh. 21 - Prob. 5MCQCh. 21 - Prob. 6MCQCh. 21 - Prob. 7MCQCh. 21 - Prob. 8MCQCh. 21 - Prob. 9MCQCh. 21 - Since a tunicate is considered to be a chordate,...Ch. 21 - Prob. 11MCQCh. 21 - Prob. 12MCQCh. 21 - How do reptiles and mammals differ from...Ch. 21 - Prob. 14MCQCh. 21 - Since a whale is a mammal, it must a. have scales....Ch. 21 - Compare the nine major animal phyla in the order...Ch. 21 - Prob. 2WIOCh. 21 - Prob. 3WIOCh. 21 - Distinguish between (a) radial and bilateral...Ch. 21 - Prob. 5WIOCh. 21 - Prob. 6WIOCh. 21 - Prob. 7WIOCh. 21 - Compare and contrast the roundworm body structure...Ch. 21 - Make a chart showing the characteristics of each...Ch. 21 - List the features that determine the echinoderms...Ch. 21 - Prob. 11WIOCh. 21 - How do tunicates and lancelets differ from fishes...Ch. 21 - Draw from memory a phylogenetic tree that traces...Ch. 21 - Prob. 14WIOCh. 21 - List five adaptations that enable (a) fishes to...Ch. 21 - Prob. 16WIOCh. 21 - Prob. 17WIOCh. 21 - Summarize the evidence for the idea that birds are...Ch. 21 - Prob. 19WIOCh. 21 - Prob. 20WIOCh. 21 - How are fishes, amphibians, nonavian reptiles,...Ch. 21 - Give three examples of interactions between...Ch. 21 - Prob. 23WIOCh. 21 - Prob. 24WIOCh. 21 - Prob. 1PITCh. 21 - Prob. 2PITCh. 21 - 3. Draw a concept map that summarizes the...
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