ANATOMY & PHYSIOLOGY LL W/CONNECT ACCESS
4th Edition
ISBN: 9781265521363
Author: McKinley
Publisher: MCG
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Textbook Question
Chapter 21, Problem 2CAL
A child born without his thymus would not have mature
- a. macrophages.
- b. B-lymphocytes.
- c. dendritic cells.
- d. T-lymphocytes.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 21 Solutions
ANATOMY & PHYSIOLOGY LL W/CONNECT ACCESS
Ch. 21.1 - What substances typically are absorbed from the...Ch. 21.1 - Prob. 2WDYLCh. 21.1 - Prob. 3WDYLCh. 21.1 - Which major body regions drain lymph to the right...Ch. 21.2 - How are primary lymphatic structures and secondary...Ch. 21.3 - Why is red bone marrow considered a primary...Ch. 21.3 - Prob. 7WDYLCh. 21.4 - Prob. 8WDYLCh. 21.4 - What are the general functions of the spleen?...Ch. 21.4 - Prob. 10WDYL
Ch. 21.4 - Prob. 11WDYLCh. 21.4 - What is the function of MALT in the mucosal...Ch. 21 - Prob. 1DYKBCh. 21 - _____ 2. Lymph is drained into the thoracic duct...Ch. 21 - _____ 3. The spleen is a secondary lymphatic...Ch. 21 - Prob. 4DYKBCh. 21 - _____ 5. Which type of lymph vessel consists...Ch. 21 - _____ 6. Which statement is accurate about lymph...Ch. 21 - In an early Streptococcus infection of the throat,...Ch. 21 - _____ 8. The lymphatic trunk that drains lymph...Ch. 21 - _____ 9. Aged erythrocytes are removed from...Ch. 21 - _____ 10. Interstitial fluid that is absorbed into...Ch. 21 - Prob. 11DYKBCh. 21 - Prob. 12DYKBCh. 21 - Prob. 13DYKBCh. 21 - Which body regions have their lymph drained to the...Ch. 21 - Describe how the thymuss anatomy changes as we...Ch. 21 - Prob. 16DYKBCh. 21 - Compare and contrast the red and white pulp of the...Ch. 21 - Describe the specific locations of the tonsils.Ch. 21 - Describe the location and function of diffuse...Ch. 21 - Prob. 20DYKBCh. 21 - Prob. 1CALCh. 21 - A child born without his thymus would not have...Ch. 21 - Prob. 3CALCh. 21 - Prob. 4CALCh. 21 - Prob. 5CALCh. 21 - Prob. 1CSLCh. 21 - Jordan has an enlarged lymph node along the side...Ch. 21 - Prob. 3CSL
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