ANATOMY+PHYSIOLOGY
4th Edition
ISBN: 9781260265217
Author: McKinley
Publisher: RENT MCG
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Chapter 2.1, Problem 1WDYL
How would the chemical shorthand for oxygen be written?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 2 Solutions
ANATOMY+PHYSIOLOGY
Ch. 2.1 - How would the chemical shorthand for oxygen be...Ch. 2.1 - Diagram the atomic structure of chlorineatomic...Ch. 2.1 - Do isotopes represent the same element? Do they...Ch. 2.1 - Prob. 4WDYLCh. 2.2 - List the common cations and anions of the human...Ch. 2.2 - Prob. 6WDYLCh. 2.2 - Explain how and why ions form based on the octet...Ch. 2.2 - Could an ionic bond form between two cations or...Ch. 2.3 - Prob. 9WDYLCh. 2.3 - What is an isomer?
Ch. 2.3 - Explain covalent bond formation in terms of...Ch. 2.3 - Assign the partial charges between nitrogen and...Ch. 2.3 - Why are some covalent bonds nonpolar and others...Ch. 2.3 - Are O2, and CO2 nonpolar or polar molecules?Ch. 2.3 - What is the name of the intermolecular attraction...Ch. 2.4 - Diagram the intermolecular bond between water...Ch. 2.4 - Prob. 17WDYLCh. 2.4 - Prob. 18WDYLCh. 2.4 - Prob. 19WDYLCh. 2.5 - Explain why water is neutral.Ch. 2.5 - Which type of substance releases H+ when added to...Ch. 2.5 - What is the general relationship of [H+] and pH?Ch. 2.5 - Why are buffers important and how do they function...Ch. 2.6 - Prob. 24WDYLCh. 2.6 - Why is blood also considered the other two types...Ch. 2.6 - What are four ways solution concentration may be...Ch. 2.7 - Prob. 27WDYLCh. 2.7 - What functional groups may act as an acid?Ch. 2.7 - What defines a polymer? List the three...Ch. 2.7 - Do lipid molecules typically dissolve in water?...Ch. 2.7 - Which class of lipids forms cell membranes? What...Ch. 2.7 - What is the repeating monomer of glycogen? Where...Ch. 2.7 - For each of the following, indicate if it is a...Ch. 2.7 - What is the general function of nucleic acids?Ch. 2.7 - What are the structural differences between RNA...Ch. 2.7 - What are the monomers of proteins and the name of...Ch. 2.7 - Prob. 37WDYLCh. 2.8 - Prob. 38WDYLCh. 2.8 - Prob. 39WDYLCh. 2.8 - Prob. 40WDYLCh. 2 - Prob. 1DYKBCh. 2 - _____ 2. Substances that dissolve in water include...Ch. 2 - _____ 3. Temperature stabilization is dependent...Ch. 2 - _____ 4. All of the following are accurate about...Ch. 2 - _____ 5. Blood is a mixture that is more...Ch. 2 - Prob. 6DYKBCh. 2 - _____ 7. Glucose is stored as which molecule...Ch. 2 - Prob. 8DYKBCh. 2 - Prob. 9DYKBCh. 2 - _____ 10. When a protein permanently unfolds, it...Ch. 2 - List the common ions of the human body by name,...Ch. 2 - Describe a polar bond and a polar molecule.Ch. 2 - Diagram two water molecules and label the polar...Ch. 2 - Compare and contrast what occurs when a substance...Ch. 2 - Define the terms acid, base, PH, and buffers.Ch. 2 - Explain the units for expressing a concentration...Ch. 2 - List the four organic biomolecules and the...Ch. 2 - Which two organic biomolecules contain nitrogen...Ch. 2 - Describe how phospholipid molecules form the...Ch. 2 - Explain protein denaturation, including bow it...Ch. 2 - Which property of water is significant in children...Ch. 2 - Prob. 2CALCh. 2 - Prob. 3CALCh. 2 - The condition of rickets involves bones that have...Ch. 2 - The hormone insulin is a __________ composed of...Ch. 2 - An individual is exposed to high-energy radiation....Ch. 2 - The lab results from a diabetic patient show a...Ch. 2 - Prob. 3CSL
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