BIO 1406/07 BK/LAB/CODE PREPACK
12th Edition
ISBN: 9781265538590
Author: Raven
Publisher: MCG
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Chapter 20.1, Problem 1LO
Define evolution and population genetics.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 20 Solutions
BIO 1406/07 BK/LAB/CODE PREPACK
Ch. 20.1 - Define evolution and population genetics.Ch. 20.1 - Prob. 2LOCh. 20.2 - Explain the HardyWeinberg principle.Ch. 20.2 - Describe the characteristics of a population that...Ch. 20.2 - Prob. 3LOCh. 20.3 - Define the five processes that can cause...Ch. 20.3 - Prob. 2LOCh. 20.4 - Prob. 1LOCh. 20.4 - Prob. 2LOCh. 20.4 - Demonstrate how the success of different...
Ch. 20.5 - Prob. 1LOCh. 20.5 - Prob. 2LOCh. 20.5 - Prob. 3LOCh. 20.6 - Define frequency-dependent selection, oscillating...Ch. 20.6 - Prob. 2LOCh. 20.7 - Define and contrast disruptive, directional, and...Ch. 20.7 - Prob. 2LOCh. 20.8 - Explain how experiments can be used to test...Ch. 20.9 - Prob. 1LOCh. 20.9 - Prob. 2LOCh. 20.10 - Prob. 2LOCh. 20 - If all white cats died, what proportion of the...Ch. 20 - Assuming that the values on the x-axis represent...Ch. 20 - Prob. 3DACh. 20 - Prob. 4DACh. 20 - Examine the index of copper tolerance on nonmine...Ch. 20 - Prob. 6DACh. 20 - Why are rare alleles particularly likely to be...Ch. 20 - Prob. 2IQCh. 20 - Prob. 3IQCh. 20 - Prob. 4IQCh. 20 - Prob. 5IQCh. 20 - Prob. 6IQCh. 20 - Prob. 7IQCh. 20 - Prob. 8IQCh. 20 - Prob. 9IQCh. 20 - Assortative mating a. affects genotype frequencies...Ch. 20 - When the environment changes from year to year and...Ch. 20 - Many factors can limit the ability of natural...Ch. 20 - Stabilizing selection differs from directional...Ch. 20 - Founder effects and bottlenecks are a. expected...Ch. 20 - Relative fitness a. refers to the survival rate of...Ch. 20 - For natural selection to result in evolutionary...Ch. 20 - Prob. 8UCh. 20 - In a population of red (dominant allele) or white...Ch. 20 - Genetic drift and natural selection can both lead...Ch. 20 - Prob. 3ACh. 20 - Prob. 4ACh. 20 - In Trinidadian guppies a combination of elegant...Ch. 20 - On large, black lava flows in the deserts of the...Ch. 20 - Based on a consideration of how strong artificial...
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