BIOCHEMISTRY 2 TERM ACCESS
9th Edition
ISBN: 9781319402877
Author: BERG
Publisher: MAC HIGHER
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Chapter 20, Problem 45P
Interpretation Introduction
Interpretation:
The complete combustion of glucose yields 30 ATPs, but synthesis of glucose that only requires 18 ATPs should be discussed
If it is a violation of the first law of
Concept introduction:
First law of thermodynamics is related to the conservation of energy. It states that the total energy of an isolated system remains constant. Energy can neither be created nor be destroyed. Energy can only be transformed from one form to another.
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The mitochondrial ATP synthase has 10 copies of the F0 subunit “c”, and the [H ] in the mitochondrial inner membrane space (IMS) is 6.31 x 10-8 M and the [H + ] in the matrix is 3.16 x 10-9 M. Calculate the minimum membrane potential (∆Ψ) necessary to make ATP synthesis thermodynamically favorable. [Assume ∆G' ofphosphate hydrolysis of ATP is - 45 kJ/mol.]
B- Vitamins are converted readily into important metabolic cofactors. Deficiency in any one of them has serious side effects.
a. The disease beriberi results from a vitamin B 1 (Thiamine) deficiency and is characterized by cardiac and neurological symptoms. One key diagnostic for this disease is an increased level of pyruvate and α-ketoglutarate in the bloodstream. How does this vitamin deficiency lead to increased serumlevels of these factors?
b. What would you expect the effect on the TCA intermediates for a patient suffering from vitamin B 5 deficiency?
c. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 2 /B 3 deficiency?
Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvate dehydrogenase complex, resulting in acetyl-CoA and CO2. Provide a full mechanism for this reaction utilizing the TPP cofactor. Include the roles of all cofactors.
Chapter 20 Solutions
BIOCHEMISTRY 2 TERM ACCESS
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