Chapter 2, Problem 41P

Consider the cystic fibrosis pedigree in Figure 2.24a.

a.	Assuming that one of the individuals in generation I was a carrier, and that no one from outside the family was a carrier, what was the probability that any single child of the consanguineous couple in generation V would have cystic fibrosis? (Assume that none of their children is born yet, so you don’t know that VI-4 has the disease.)
b.	Assuming that one of the individuals in generation I was a carrier and that 1/1000 people in the population is a carrier, and knowing that VI-4 has the disease, how likely was it that VII-1 would be affected?