Microbiology: An Introduction
Microbiology: An Introduction
11th Edition
ISBN: 9780321733603
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case
Publisher: Benjamin Cummings
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Chapter 2, Problem 3CAE

Newborn babies are tested for phenylketonuria (PKU), an inherited disease. Individuals with this disease are missing an enzyme to convert phenylalanine (phe) to tyrosine; the resulting accumulation of phe can cause mental retardation, brain damage, and seizures. The Guthrie test for PKU involves culturing Bacillus subtilis, which requires phe to grow. The bacteria are grown on media with a drop of the baby’s blood.

  1. a. What type of chemical is phenylalanine?
  2. b. What does “no growth” in the Guthrie test mean?
  3. c. Why must individuals with PKU avoid the sweetener aspartame?
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