The lipids that would be found in the human cell membrane. Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

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Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Expert Solution & Answer

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Check out a sample textbook solution

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Answer 3

Question

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Expert Solution & Answer

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Answer 4

Question

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Expert Solution & Answer

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Check out a sample textbook solution

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Answer 5

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Answer 6

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Answer 7

Chapter 2, Problem 23CP

Summary Introduction

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Answer 8

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Ch. 2 - Prob. 1LO Ch. 2 - Prob. 2LO Ch. 2 - Prob. 3LO Ch. 2 - Prob. 4LO Ch. 2 - Prob. 5LO Ch. 2 - Learning Outcome Explain how the chemical...Ch. 2 - Learning Outcome Describe the pH scale and the...Ch. 2 - Learning Outcome Describe the functional roles of...Ch. 2 - Prob. 9LO Ch. 2 - Prob. 10LO

The lipids that would be found in the human cell membrane. Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

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To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Want to see the full answer?

Chapter 2 Solutions

The lipids that would be found in the human cell membrane. Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Concept explainers

Videos

To determine: The lipids that would be found in the human cell membrane. Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.

Want to see the full answer?

Chapter 2 Solutions

To determine: The lipids that would be found in the human cell membrane.

Introduction: Lipids are the main constituents of plant and animal cells and are insoluble in water and soluble in alcohol, ether, and chloroform.