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Anatomy and Physiology: An Integrative Approach with Connect Access Card
3rd Edition
ISBN: 9781260254440
Author: Michael McKinley, Valerie O'Loughlin, Theresa Bidle
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 19.3, Problem 14WDL
What are the layers of the heart (in order) that a scalpel would pass through during dissection? What are the two names given to the outer layer of the heart wall?
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Please answer the following chart so I can understand how to do it.
Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 19 Solutions
Anatomy and Physiology: An Integrative Approach with Connect Access Card
Ch. 19.1 - Prob. 1LOCh. 19.1 - WHAT DID YOU LEARN?
1 Define perfusion. Why would...Ch. 19.1 - Prob. 2LOCh. 19.1 - LEARNING OBJECTIVE
3. Describe the general...Ch. 19.1 - WHAT DO YOU THINK?
1 What vessels attached to the...Ch. 19.1 - Prob. 2WDLCh. 19.1 - Prob. 3WDLCh. 19.1 - Prob. 4WDLCh. 19.1 - Prob. 5WDLCh. 19.1 - Prob. 4LO
Ch. 19.1 - What path does blood follow through the heart?...Ch. 19.1 - Which of the great vessels is both an artery and...Ch. 19.2 - LEARNING OBJECTIVE
5. Describe the location and...Ch. 19.2 - Prob. 8WDLCh. 19.2 - Prob. 9WDLCh. 19.2 - Prob. 6LOCh. 19.2 - Prob. 7LOCh. 19.2 - Describe the three layers that cover the heart....Ch. 19.3 - LEARNING OBJECTIVE
8. Compare the superficial...Ch. 19.3 - Prob. 11WDLCh. 19.3 - Prob. 12WDLCh. 19.3 - Prob. 13WDLCh. 19.3 - Prob. 9LOCh. 19.3 - What are the layers of the heart (in order) that a...Ch. 19.3 - Prob. 10LOCh. 19.3 - What is the structure that separates the two...Ch. 19.3 - Prob. 16WDLCh. 19.3 - Prob. 11LOCh. 19.3 - What are the functions of the tendinous cords and...Ch. 19.3 - Prob. 12LOCh. 19.3 - Which function of the fibrous skeleton allows the...Ch. 19.3 - Prob. 13LOCh. 19.3 - Prob. 14LOCh. 19.3 - Prob. 15LOCh. 19.3 - Which features of cardiac muscle support aerobic...Ch. 19.4 - Prob. 16LOCh. 19.4 - Prob. 17LOCh. 19.4 - Prob. 18LOCh. 19.4 - Prob. 2WDTCh. 19.4 - What areas of the heart are deprived of blood when...Ch. 19.4 - Prob. 19LOCh. 19.4 - Prob. 21WDLCh. 19.5 - Prob. 20LOCh. 19.5 - Prob. 22WDLCh. 19.5 - Prob. 21LOCh. 19.5 - Which autonomic division is associated with the...Ch. 19.6 - LEARNING OBJECTIVE
22. Describe a nodal cell at...Ch. 19.6 - Prob. 24WDLCh. 19.6 - Prob. 23LOCh. 19.6 - Prob. 24LOCh. 19.6 - Prob. 3WDTCh. 19.6 - What is autorhythmicity? Describe how nodal cells...Ch. 19.6 - Prob. 25LOCh. 19.6 - What is the path of an action potential through...Ch. 19.6 - What anatomic features slow the conduction rate of...Ch. 19.7 - Prob. 26LOCh. 19.7 - In which direction does Ca2+ move in response to...Ch. 19.7 - Prob. 27LOCh. 19.7 - Prob. 28LOCh. 19.7 - Prob. 4WDTCh. 19.7 - What three electrical events occur at the...Ch. 19.7 - Prob. 29LOCh. 19.7 - Prob. 30LOCh. 19.7 - What is the significance of the extended...Ch. 19.7 - Prob. 31LOCh. 19.7 - What events in the heart are indicated by each of...Ch. 19.8 - Prob. 32LOCh. 19.8 - Prob. 33LOCh. 19.8 - Pressure changes that occur during the cardiac...Ch. 19.8 - Prob. 34LOCh. 19.8 - Prob. 35LOCh. 19.8 - What is occurring during ventricular ejection?Ch. 19.8 - Prob. 34WDLCh. 19.8 - Define end-diastolic volume, end-systolic volume,...Ch. 19.9 - Prob. 36LOCh. 19.9 - Prob. 37LOCh. 19.9 - What are the two factors that determine cardiac...Ch. 19.9 - What is the cardiac output at rest and during...Ch. 19.9 - Prob. 38LOCh. 19.9 - Prob. 39LOCh. 19.9 - Prob. 38WDLCh. 19.9 - Describe the atrial reflex, which involves...Ch. 19.9 - Prob. 40LOCh. 19.9 - Prob. 41LOCh. 19.9 - Prob. 40WDLCh. 19.9 - Prob. 42LOCh. 19.9 - Prob. 41WDLCh. 19.10 - Prob. 43LOCh. 19.10 - Prob. 44LOCh. 19.10 - Prob. 42WDLCh. 19 - Which of the following is the correct circulatory...Ch. 19 - The pericardial cavity is located between the a....Ch. 19 - How is blood prevented from backflowing from the...Ch. 19 - ____ 4. Venous blood draining from the heart wall...Ch. 19 - _____ 5. Calcium channels in the nodal cells...Ch. 19 - ____6. Action potentials are spread rapidly...Ch. 19 - Why is it necessary to stimulate papillary muscles...Ch. 19 - ____ 8. Preload is a measure of a. stretch of...Ch. 19 - ____ 9. All of the following occur when the...Ch. 19 - ____10. What occurs during the atrial reflex? a....Ch. 19 - Prob. 11DYBCh. 19 - Compare the structure, location, and function of...Ch. 19 - Prob. 13DYBCh. 19 - Explain why the walls of the atria are thinner...Ch. 19 - Describe the structure and function of...Ch. 19 - Explain the general location and function of...Ch. 19 - Describe the functional differences in the effects...Ch. 19 - Prob. 18DYBCh. 19 - List the five events of the cardiac cycle, and...Ch. 19 - Define cardiac output, and explain how it is...Ch. 19 - A young man was doing some vigorous exercise when...Ch. 19 - A young man was doing some vigorous exercise when...Ch. 19 - Prob. 3CALCh. 19 - Prob. 4CALCh. 19 - During surgery, the right vagus nerve was...Ch. 19 - Prob. 1CSLCh. 19 - Prob. 2CSLCh. 19 - Your grandfather was told that his SA node...
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