Genetics: Analysis and Principles
Genetics: Analysis and Principles
5th Edition
ISBN: 9780073525341
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 19.2, Problem 2COMQ

During site-specific recombination that occurs in an antibody gene, the protein(s) that catalyze(s) the joining of V and J domains to each other is/are

a. RAG1 and RAG2.

b. nonhomologous end-joining (NHEJ) proteins.

c. RecA.

d. RecBCD.

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Plekhg5 functions in bottle cell formation, and Shroom3 functions in neural plate closure, yet the phenotype of injecting mRNA of each into the animal pole of a fertilized egg is very similar. What is the phenotype, and why is the phenotype so similar? Is the phenotype going to be that there is a disruption of the formation of the neural tube for both of these because bottle cell formation is necessary for the neural plate to fold in forming the neural tube and Shroom3 is further needed to close the neural plate? So since both Plekhg5 and Shroom3 are used in forming the neural tube, injecting the mRNA will just lead to neural tube deformity?
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Genetics: Analysis and Principles

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