Concept explainers
What type of cells would develop if you injected embryos with a reagent that blocked the FGF receptor, thus preventing its signaling? What about with a reagent that turned on the FGF receptor, thereby causing it to be always on?

To determine: The cells that would develop even after blocking FGF receptor and the effect on persistently active FGF receptor.
Introduction: Colony-stimulating factors (CSF) are the molecules that are a combination of polysaccharide and protein; thus, called glycoproteins. These are the factors that help in stimulating the production, proliferation and differentiation of various types of blood cells in the body.
Explanation of Solution
The different cells of the body undergo diverse cell fate due to molecule signalling and decision-making. The FGF (fibroblast growth factor) receptor is important protein receptor that regulates the growth of fibroblasts. The cells that will keep on dividing and differentiating after adding a reagent that blocks FGF receptor are the muscle precursor cells and nerve cord precursor cells. This is because the muscle precursor cells and nerve cord precursor cells do not have FGF receptor, and therefore its blocking willnot affect its functioning. On adding a reagent that persistently activates FGF receptor or over activates it can result in the various pathological conditions like unregulated cell growth, tumour genesis, and skeletal abnormalities like achondroplasia and craniosynostosis.
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Chapter 19 Solutions
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