(a) Interpretation: The missing reactant that is necessary to carry out the given transformation is to be drawn. Concept introduction: The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B ( OR” ) 2 and a palladium catalyst ( PdLn ) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C , then R and the substituent will be trans to each other in the product.

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Answer 1

Question

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

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Answer 2

Question

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

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Answer 3

Question

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

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Answer 4

Question

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

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Answer 5

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Answer 6

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Answer 7

Chapter 19, Problem 19.60P

Interpretation Introduction

(a)

Interpretation:

The missing reactant that is necessary to carry out the given transformation is to be drawn.

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Answer 8

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Answer 9

Interpretation Introduction

(b)

Interpretation:

Concept introduction:

The palladium catalysed reactions are namely Suzuki coupling and Heck coupling which form a new C-C bond. In Suzuki coupling reaction, a vinylic or aryl halide R-X is treated with an organometallic compound R’-B(OR”)2 and a palladium catalyst (PdLn) under basic conditions. Suzuki reaction is stereospecific involving possible E/Z isomerism usually with retention of configuration. Similar to the Suzuki reaction, the Heck reaction can couple one vinylic or aryl group to another. If R-X halide in a Heck reaction is vinylic, the configuration about the double bond is retained. If H-R’ is vinylic and has an attached substituent at the opposite end of the C=C, then R and the substituent will be trans to each other in the product.

Answer 10

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Answer 12

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Answer 13

Ch. 19 - Prob. 19.1P Ch. 19 - Prob. 19.2P Ch. 19 - Prob. 19.3P Ch. 19 - Prob. 19.4P Ch. 19 - Prob. 19.5P Ch. 19 - Prob. 19.6P Ch. 19 - Prob. 19.7P Ch. 19 - Prob. 19.8P Ch. 19 - Prob. 19.9P Ch. 19 - Prob. 19.10P

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