The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid. Introduction: In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

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Answer 1

Question

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

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10. Your instructor will give you 2 amino acids during the activity session (video 2-7. A. First color all the polar and non-polar covalent bonds in the R groups of your 2 amino acids using the same colors as in #7. Do not color the bonds in the backbone of each amino acid. B. Next, color where all the hydrogen bonds, hydrophobic interactions and ionic bonds could occur in the R group of each amino acid. Use the same colors as in #7. Do not color the bonds in the backbone of each amino acid. C. Position the two amino acids on the page below in an orientation where the two R groups could bond together. Once you are satisfied, staple or tape the amino acids in place and label the bond that you formed between the two R groups. - Polar covalent Bond - Red - Non polar Covalent boND- yellow - Ionic BonD - PINK Hydrogen Bonn - Purple Hydrophobic interaction-green O=C-N H I. H HO H =O CH2 C-C-N HICK H HO H CH2 OH H₂N C = O

Find the dental formula and enter it in the following format: I3/3 C1/1 P4/4 M2/3 = 42 (this is not the correct number, just the correct format) Please be aware: the upper jaw is intact (all teeth are present). The bottom jaw/mandible is not intact. The front teeth should include 6 total rectangular teeth (3 on each side) and 2 total large triangular teeth (1 on each side).

Answer 2

Question

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

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Answer 3

Question

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

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Answer 4

Question

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

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Answer 5

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

Answer 6

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

Answer 7

Chapter 18.3, Problem 8SAQ

Summary Introduction

To determine:

The change in the binding of large multisubunit protein when it binds to a small molecule no larger than one amino acid.

Introduction:

In genetic diversity the gene may be regulated in two directions one is negative regulation and other is positive regulation. To carry out the process of transcription and translation we need the main player such as DNA, RNA polymerase, and regulatory proteins which are together called as transcriptional activator. The function of activator protein involves the binding to DNA specific sequence. But sometimes it happens that the activator protein binds to the small protein molecules that alter its binding affinity for DNA.

Answer 8

Expert Solution & Answer

Explanation of Solution

When the large protein molecule binds with a small molecule of protein it leads to conformational change in the part of protein. The binding affinity of the protein alters due to change in the shape and this shows allosteric effect. Sometimes small molecules are needed for the binding of proteins to a particular sequence of DNA as it allows the change in the shape of activator protein. Thus the presence of small molecules regulates the transcription of gene. The combination of small molecule to a large protein brings structural change and its specificity for the original DNA binding site changes. It generates a new and different DNA binding specificity due to exposure of a new amino acid chains.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Conclusion

The binding of small molecule to a larger and multisubunit protein results in the structural change of protein. This results in the alteration of the amino acid change and thus the specificity for DNA binding site changes. Sometimes small molecule play significant role for binding of the protein molecule to a specific DNA sequence.

Answer 12

Ch. 18.1 - Prob. 1SAQ Ch. 18.1 - Prob. 2SAQ Ch. 18.1 - Prob. 3SAQ Ch. 18.1 - Prob. 4SAQ Ch. 18.1 - Prob. 5SAQ Ch. 18.2 - Prob. 6SAQ Ch. 18.2 - Prob. 7SAQ Ch. 18.3 - Prob. 8SAQ Ch. 18.3 - Prob. 9SAQ Ch. 18.3 - Prob. 10SAQ

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