CONNECT FOR SEELEY'S ANAT & PHYS
12th Edition
ISBN: 9781264052325
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 18.3, Problem 29AYP
Summary Introduction
To determine:
The conditions that cause hypothyroidism and the effects of hyposecretion of thyroid hormones.
Introduction:
Thyroid-stimulating hormone (TSH) is an anterior pituitary hormone that stimulates synthesis and secretion of the thyroid hormone. It increases the synthesis of T3 and T4 (store in a large protein called thyroglobulin), and their release from thyroglobulin.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 18 Solutions
CONNECT FOR SEELEY'S ANAT & PHYS
Ch. 18.1 - Prob. 1AYPCh. 18.1 - Prob. 2AYPCh. 18.2 - Prob. 3AYPCh. 18.2 - Prob. 4AYPCh. 18.2 - How does the hypothalamus regulate the secretion...Ch. 18.2 - Prob. 6AYPCh. 18.2 - Prob. 7AYPCh. 18.2 - Prob. 8AYPCh. 18.2 - Prob. 9AYPCh. 18.2 - Prob. 10AYP
Ch. 18.2 - Prob. 11AYPCh. 18.2 - Prob. 12AYPCh. 18.2 - Prob. 13AYPCh. 18.2 - What effects do stress, blood amino acid levels,...Ch. 18.2 - Describe the effects of GH on its target tissues.Ch. 18.2 - Prob. 16AYPCh. 18.2 - Prob. 17AYPCh. 18.2 - Prob. 18AYPCh. 18.2 - For each of the following hormones secreted by the...Ch. 18.2 - Prob. 20AYPCh. 18.2 - What is a gonadotropin? Name two...Ch. 18.3 - Prob. 22AYPCh. 18.3 - Prob. 23AYPCh. 18.3 - How are the thyroid hormones transported in the...Ch. 18.3 - Prob. 25AYPCh. 18.3 - Starting in the hypothalamus, explain how chronic...Ch. 18.3 - Prob. 27AYPCh. 18.3 - Prob. 28AYPCh. 18.3 - Prob. 29AYPCh. 18.3 - What conditions cause hyperthyroidism? Describe...Ch. 18.3 - Prob. 31AYPCh. 18.4 - Prob. 32AYPCh. 18.4 - Prob. 33AYPCh. 18.4 - Prob. 34AYPCh. 18.4 - Prob. 35AYPCh. 18.4 - What can cause hypoparathyroidism?Describe the...Ch. 18.4 - Prob. 37AYPCh. 18.5 - Where are the adrenal glands located? Describe the...Ch. 18.5 - Name two hormones secreted by the adrenal medulla,...Ch. 18.5 - Prob. 40AYPCh. 18.5 - Prob. 41AYPCh. 18.5 - Name the target tissue ofaldosterone, and list...Ch. 18.5 - Prob. 43AYPCh. 18.5 - Prob. 44AYPCh. 18.5 - List the possible causes of hypersecretion of...Ch. 18.5 - Prob. 46AYPCh. 18.6 - Prob. 47AYPCh. 18.6 - Prob. 48AYPCh. 18.6 - How does insulin affect the satiety center of the...Ch. 18.6 - Prob. 50AYPCh. 18.6 - Prob. 51AYPCh. 18.7 - Prob. 52AYPCh. 18.7 - Prob. 53AYPCh. 18.7 - Prob. 54AYPCh. 18.8 - Prob. 55AYPCh. 18.8 - List the hormones secreted by the ovaries, and...Ch. 18.8 - What hormones from the anterior pituitary gland...Ch. 18.8 - Prob. 58AYPCh. 18.9 - Prob. 59AYPCh. 18.9 - Prob. 60AYPCh. 18.10 - What hormone is secreted by the thymus? What is...Ch. 18.10 - Prob. 62AYPCh. 18.10 - Prob. 63AYPCh. 18.10 - Prob. 64AYPCh. 18.10 - List examples of paracrine chemical messengers...Ch. 18.10 - Prob. 66AYPCh. 18.11 - Prob. 67AYPCh. 18.11 - Prob. 68AYPCh. 18 - The pituitary gland a. develops from the floor of...Ch. 18 - The hypothalamohypophysial portal system a....Ch. 18 - Prob. 3RACCh. 18 - Prob. 4RACCh. 18 - Prob. 5RACCh. 18 - Prob. 6RACCh. 18 - Prob. 7RACCh. 18 - Hypersecretion of growth hormone a.results in...Ch. 18 - Prob. 9RACCh. 18 - Prob. 10RACCh. 18 - Prob. 11RACCh. 18 - Prob. 12RACCh. 18 - Prob. 13RACCh. 18 - Parathyroid hormone secretion increases in...Ch. 18 - Prob. 15RACCh. 18 - Prob. 16RACCh. 18 - In the condition in which a benign tumor results...Ch. 18 - Which of these is nor a hormone secreted by the...Ch. 18 - Prob. 19RACCh. 18 - Prob. 20RACCh. 18 - Prob. 21RACCh. 18 - Within the pancreas, the pancreatic islets produce...Ch. 18 - Insulin increases a. the uptake of glucose by its...Ch. 18 - Prob. 24RACCh. 18 - Prob. 25RACCh. 18 - Prob. 26RACCh. 18 - Prob. 27RACCh. 18 - Prob. 28RACCh. 18 - Prob. 29RACCh. 18 - Prob. 30RACCh. 18 - Prob. 1CTCh. 18 - Prob. 2CTCh. 18 - A patient complains of headaches and visual...Ch. 18 - Prob. 4CTCh. 18 - Prob. 5CTCh. 18 - Prob. 6CTCh. 18 - Prob. 7CTCh. 18 - Predict some of the consequences of exposure to...Ch. 18 - Katie was getting nervous. At 16, she was the only...
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