Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
6th Edition
ISBN: 9780135213001
Author: Cindy Stanfield
Publisher: PEARSON+
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Chapter 17.4, Problem 17.3.3QC
Summary Introduction
To predict:The chemical equation catalysed by the enzyme carbonic anhydrase.
Introduction:Carbonic anhydrase is an enzyme present in RBC that balances the pH of the blood and enables the breathing out of CO2. This enzyme catalyses a reaction in breathing process.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 17 Solutions
Pearson eText Principles of Human Physiology -- Instant Access (Pearson+)
Ch. 17.2 - Prob. 17.1.1QCCh. 17.2 - If the cells of the body consume 300 mL of oxygen...Ch. 17.2 - Prob. 17.1.3QCCh. 17.3 - Prob. 1CTQCh. 17.3 - Prob. 2CTQCh. 17.3 - Prob. 3CTQCh. 17.3 - Prob. 17.2.1QCCh. 17.3 - Prob. 17.2.2QCCh. 17.3 - Prob. 17.2.3QCCh. 17.3 - What happens to alveolar
when a person...
Ch. 17.4 - Prob. 1CTQCh. 17.4 - Explain the cause of pulmonary edema, and how it...Ch. 17.4 - How are the symptoms of pulmonary edema treated?
Ch. 17.4 - Prob. 17.3.1QCCh. 17.4 - Prob. 17.3.2QCCh. 17.4 - Prob. 17.3.3QCCh. 17.5 - Prob. 17.4.1QCCh. 17.5 - Prob. 17.4.2QCCh. 17.5 - Prob. 17.4.3QCCh. 17.6 - Prob. 17.5.1QCCh. 17.6 - Which stimuli activate the peripheral...Ch. 17.7 - Prob. 17.6.1QCCh. 17.7 - What effect does a decrease in
in the...Ch. 17.7 - Prob. 17.6.3QCCh. 17.8 - Prob. 17.7.1QCCh. 17.8 - Prob. 17.7.2QCCh. 17 - Prob. 1ECh. 17 - Prob. 2ECh. 17 - Prob. 3ECh. 17 - Which of the following does not affect alveolar...Ch. 17 - During hyperventilation, which of the following...Ch. 17 - Prob. 6ECh. 17 - Prob. 7ECh. 17 - Prob. 8ECh. 17 - Prob. 9ECh. 17 - Prob. 10ECh. 17 - Prob. 11ECh. 17 - Prob. 12ECh. 17 - Which of the following areas of the brain contain...Ch. 17 - Prob. 14ECh. 17 - Prob. 15ECh. 17 - Prob. 16ECh. 17 - Prob. 17ECh. 17 - Prob. 18ECh. 17 - Prob. 19ECh. 17 - Prob. 20ECh. 17 - Prob. 21ECh. 17 - Prob. 22ECh. 17 - Prob. 23ECh. 17 - (Central/Peripheral) chemoreceptors respond...Ch. 17 - Coughing is triggered by stimulation of pulmonary...Ch. 17 - In respiratory acidosis, arterial is...Ch. 17 - 27. An increase in the
of alveolar air would be...Ch. 17 - Prob. 28ECh. 17 - Prob. 29ECh. 17 - Sketch a hemoglobin-oxygen dissociation curve, and...Ch. 17 - Prob. 31ECh. 17 - Prob. 32ECh. 17 - Prob. 33ECh. 17 - Prob. 34ECh. 17 - Prob. 35ECh. 17 - Barbiturate overdoses cause respiratory...Ch. 17 - Prob. 37E
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