Campbell Biology & Alkaline Vents Supplemental Materials for Campbell Biology & Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology Package
Campbell Biology & Alkaline Vents Supplemental Materials for Campbell Biology & Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology Package
1st Edition
ISBN: 9780133984293
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 17.3, Problem 3CC
Summary Introduction

To determine: The effect on the cells that are treated with an agent which caused the removal of cap from messenger RNAs (mRNAs).

Concept introduction:

After transcription, pre-mRNA is synthesized and further modified before translation in the cytoplasm. This is called the RNA processing and it includes the modification of mRNA ends and RNA splicing. A modified guanine (7-methyl guanine) group is added to the 5′ end of the mRNA chain with the help of the capping enzymes. This is known as the 5′ cap. At the 3′ end of the eukaryotic mRNA chain, adenine groups (poly-A tail) are added by poly (A) polymerase enzyme. This is known as the polyadenylation.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.

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Campbell Biology & Alkaline Vents Supplemental Materials for Campbell Biology & Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology Package

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