Laboratory Manual for Human Anatomy
5th Edition
ISBN: 9781259683831
Author: Eric Wise, Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17, Problem 5TOF
Determine which five of the following statements are false, and briefly explain why.
Filiform papillae of the tongue have no taste buds.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
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c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
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3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 17 Solutions
Laboratory Manual for Human Anatomy
Ch. 17.1 - Prob. 1AWYKCh. 17.1 - Distinguish between general and special senses.Ch. 17.1 - Three schemes of receptor classification were...Ch. 17.1 - Prob. 3BYGOCh. 17.1 - Prob. 4BYGOCh. 17.1 - Prob. 5BYGOCh. 17.1 - Prob. 6BYGOCh. 17.2 - Prob. 1AWYKCh. 17.2 - What is the difference between a lingual papilla...Ch. 17.2 - Prob. 8BYGO
Ch. 17.2 - What part of an olfactory cell bears the binding...Ch. 17.2 - Prob. 10BYGOCh. 17.3 - Prob. 1AWYKCh. 17.3 - What is the benefit of having three auditory...Ch. 17.3 - Prob. 12BYGOCh. 17.3 - How does the brain recognize the difference...Ch. 17.3 - Prob. 14BYGOCh. 17.3 - Prob. 15BYGOCh. 17.4 - Prob. 1AWYKCh. 17.4 - Prob. 2AWYKCh. 17.4 - Prob. 3AWYKCh. 17.4 - Prob. 16BYGOCh. 17.4 - List as many structural and functional differences...Ch. 17.4 - Prob. 18BYGOCh. 17.4 - Prob. 19BYGOCh. 17.5 - Describe the contributions of the first pharyngeal...Ch. 17.5 - Prob. 21BYGOCh. 17.5 - Prob. 22BYGOCh. 17.5 - Prob. 23BYGOCh. 17 - The meaning of sensory receptor and the range of...Ch. 17 - Prob. 17.1.2AYLOCh. 17 - Prob. 17.1.3AYLOCh. 17 - Prob. 17.1.4AYLOCh. 17 - Prob. 17.1.5AYLOCh. 17 - The types of sensory nerve endings considered to...Ch. 17 - Prob. 17.1.7AYLOCh. 17 - Prob. 17.1.8AYLOCh. 17 - Prob. 17.1.9AYLOCh. 17 - Prob. 17.1.10AYLOCh. 17 - Prob. 17.1.11AYLOCh. 17 - Prob. 17.1.12AYLOCh. 17 - Prob. 17.1.13AYLOCh. 17 - The relationship of taste buds to the lingual...Ch. 17 - Prob. 17.2.2AYLOCh. 17 - Prob. 17.2.3AYLOCh. 17 - Prob. 17.2.4AYLOCh. 17 - Prob. 17.2.5AYLOCh. 17 - Prob. 17.2.6AYLOCh. 17 - Prob. 17.2.7AYLOCh. 17 - Prob. 17.3.1AYLOCh. 17 - Prob. 17.3.2AYLOCh. 17 - The parts of the middle ear, including its three...Ch. 17 - Prob. 17.3.4AYLOCh. 17 - The anatomy of the cochlea and the functional...Ch. 17 - Prob. 17.3.6AYLOCh. 17 - How cochlear function enables the brain to...Ch. 17 - Prob. 17.3.8AYLOCh. 17 - The differences between static and dynamic...Ch. 17 - Prob. 17.3.10AYLOCh. 17 - The action of the otolithic membrane in...Ch. 17 - Prob. 17.3.12AYLOCh. 17 - Prob. 17.3.13AYLOCh. 17 - The projection pathways taken by signals of...Ch. 17 - Prob. 17.4.1AYLOCh. 17 - Prob. 17.4.2AYLOCh. 17 - Prob. 17.4.3AYLOCh. 17 - Prob. 17.4.4AYLOCh. 17 - Prob. 17.4.5AYLOCh. 17 - Prob. 17.4.6AYLOCh. 17 - Prob. 17.4.7AYLOCh. 17 - Prob. 17.4.8AYLOCh. 17 - Prob. 17.4.9AYLOCh. 17 - The projection pathways taken by retinal signals...Ch. 17 - Prob. 17.4.11AYLOCh. 17 - Prob. 17.5.1AYLOCh. 17 - Prob. 17.5.2AYLOCh. 17 - Prob. 17.5.3AYLOCh. 17 - How the lens, vitreous body, anterior chamber,...Ch. 17 - Hot and cold stimuli are detected by free nerve...Ch. 17 - Prob. 2TYRCh. 17 - Prob. 3TYRCh. 17 - Prob. 4TYRCh. 17 - The sensory neurons that begin in the spiral organ...Ch. 17 - The spiral organ rests on the tympanic membrane....Ch. 17 - Prob. 7TYRCh. 17 - Prob. 8TYRCh. 17 - Prob. 9TYRCh. 17 - Prob. 10TYRCh. 17 - The most finely detailed vision occurs when an...Ch. 17 - Fibers of the optic nerve come from the...Ch. 17 - A sensory nerve ending specialized to detect...Ch. 17 - The gelatinous membranes of the macula sacculi and...Ch. 17 - Three rows of ____________ in the cochlea have...Ch. 17 - The __________ is a tiny bone that vibrates in the...Ch. 17 - The ___________ of the midbrain receive auditory...Ch. 17 - The apical microvilli of a gustatory cell are...Ch. 17 - Olfactory neurons synapse with mitral cells and...Ch. 17 - Prob. 20TYRCh. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - State a meaning of each word element and give a...Ch. 17 - Prob. 8BYMVCh. 17 - State a meaning of each word element and give a...Ch. 17 - Prob. 10BYMVCh. 17 - Determine which five of the following statements...Ch. 17 - Briefly explain why each of the following...Ch. 17 - Prob. 3TOFCh. 17 - Briefly explain why each of the following...Ch. 17 - Determine which five of the following statements...Ch. 17 - Prob. 6TOFCh. 17 - Prob. 7TOFCh. 17 - Prob. 8TOFCh. 17 - Briefly explain why each of the following...Ch. 17 - Briefly explain why each of the following...Ch. 17 - Prob. 1TYCCh. 17 - What type of cutaneous receptor enables you to...Ch. 17 - Predict the consequences of a hypothetical...Ch. 17 - Prob. 4TYCCh. 17 - Prob. 5TYC
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