Chapter 16.5, Problem 6P

Interpretation Introduction

(a)

Interpretation: The acid chloride which is needed to prepare the given ketones from benzene using a Friedel-Craft acylation is to be predicted.

Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction. ${\text{AlCl}}_{\text{3}}$ is used as Lewis acid which ionizes the carbon-halogen bond of the acid chloride and forms a positively charged carbon electrophile which is resonance stabilized. Then the electrophile reacts with benzene.

Interpretation Introduction

(b)

Interpretation: The acid chloride which is needed to prepare the given ketones from benzene using a Friedel-Craft acylation is to be predicted.

Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction. ${\text{AlCl}}_{\text{3}}$ is used as Lewis acid which ionizes the carbon-halogen bond of the acid chloride and forms a positively charged carbon electrophile which is resonance stabilized. Then the electrophile reacts with benzene.

Interpretation Introduction

(c)

Interpretation: The acid chloride which is needed to prepare the given ketones from benzene using a Friedel-Craft acylation is to be predicted.

Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction. ${\text{AlCl}}_{\text{3}}$ is used as Lewis acid which ionizes the carbon-halogen bond of the acid chloride and forms a positively charged carbon electrophile which is resonance stabilized. Then the electrophile reacts with benzene.