Genomic imprinting influences inheritance patterns. Concept introduction: Humans inherit alleles one from father and one from mother. Both alleles are generally functional but in some cases, one is turned off that do not express in the offspring. This refers to the gene that is imprinted, that is, the gene from one parent is silenced and is expressed from the other parent

Question

1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

Answer 1

Question

Features of a Concept Features of a Concept Characteristics are discrete; that is, they are unitary. Genetic features have alternative forms, and each feature is inherited from one of the two parents. These are called alleles. One allele is dominant over the other allele. The dominant allele is reflected in the phenotype. Random segregation creates the gametes. The heterozygotic individuals produce gametes with an equal frequency of both alleles. Genes are unlinked; that is, different traits arise from the independent assortment.

Chapter 16.2, Problem 6LO

Summary Introduction

To explain: Genomic imprinting influences inheritance patterns.

Concept introduction: Humans inherit alleles one from father and one from mother. Both alleles are generally functional but in some cases, one is turned off that do not express in the offspring. This refers to the gene that is imprinted, that is, the gene from one parent is silenced and is expressed from the other parent

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Features of a Concept Features of a Concept Characteristics are discrete; that is, they are unitary. Genetic features have alternative forms, and each feature is inherited from one of the two parents. These are called alleles. One allele is dominant over the other allele. The dominant allele is reflected in the phenotype. Random segregation creates the gametes. The heterozygotic individuals produce gametes with an equal frequency of both alleles. Genes are unlinked; that is, different traits arise from the independent assortment.

Chapter 16.2, Problem 6LO

Summary Introduction

To explain: Genomic imprinting influences inheritance patterns.

Concept introduction: Humans inherit alleles one from father and one from mother. Both alleles are generally functional but in some cases, one is turned off that do not express in the offspring. This refers to the gene that is imprinted, that is, the gene from one parent is silenced and is expressed from the other parent

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Answer 3

Question

Features of a Concept Features of a Concept Characteristics are discrete; that is, they are unitary. Genetic features have alternative forms, and each feature is inherited from one of the two parents. These are called alleles. One allele is dominant over the other allele. The dominant allele is reflected in the phenotype. Random segregation creates the gametes. The heterozygotic individuals produce gametes with an equal frequency of both alleles. Genes are unlinked; that is, different traits arise from the independent assortment.

Chapter 16.2, Problem 6LO

Summary Introduction

To explain: Genomic imprinting influences inheritance patterns.

Concept introduction: Humans inherit alleles one from father and one from mother. Both alleles are generally functional but in some cases, one is turned off that do not express in the offspring. This refers to the gene that is imprinted, that is, the gene from one parent is silenced and is expressed from the other parent

Expert Solution & Answer

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Check out sample textbook solution

Answer 4

Question

Features of a Concept Features of a Concept Characteristics are discrete; that is, they are unitary. Genetic features have alternative forms, and each feature is inherited from one of the two parents. These are called alleles. One allele is dominant over the other allele. The dominant allele is reflected in the phenotype. Random segregation creates the gametes. The heterozygotic individuals produce gametes with an equal frequency of both alleles. Genes are unlinked; that is, different traits arise from the independent assortment.

Chapter 16.2, Problem 6LO

Summary Introduction