Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 16.1, Problem 1ELO
Summarize the main categories of immunopathology and their medical consequences.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 16 Solutions
Foundations in Microbiology
Ch. 16.1 - Summarize the main categories of immunopathology...Ch. 16.1 - Prob. 2ELOCh. 16.1 - Explain what is meant by immunopathology and give...Ch. 16.1 - Prob. 2CYPCh. 16.1 - What is involved in the four categories of B-cell...Ch. 16.1 - What does it mean for a reaction to be immediate...Ch. 16.2 - Describe general characteristics of allergic...Ch. 16.2 - Prob. 4ELOCh. 16.2 - Prob. 5ELOCh. 16.2 - Prob. 6ELO
Ch. 16.2 - Prob. 7ELOCh. 16.2 - Prob. 8ELOCh. 16.2 - Prob. 9ELOCh. 16.2 - Prob. 5CYPCh. 16.2 - Describe several factors that influence types and...Ch. 16.2 - Prob. 7CYPCh. 16.2 - Prob. 8CYPCh. 16.2 - Prob. 9CYPCh. 16.2 - Prob. 10CYPCh. 16.2 - Outline the target organs and symptoms of the...Ch. 16.2 - Prob. 12CYPCh. 16.3 - Prob. 10ELOCh. 16.3 - Define what is meant by blood groups, explain how...Ch. 16.3 - Prob. 12ELOCh. 16.3 - Prob. 13ELOCh. 16.3 - Prob. 13CYPCh. 16.3 - Explain why the tissues of some people are...Ch. 16.3 - Prob. 15CYPCh. 16.3 - Where do we derive our natural hypersensitivities...Ch. 16.3 - Prob. 17CYPCh. 16.3 - Prob. 18CYPCh. 16.3 - Prob. 19CYPCh. 16.4 - Describe the background features of immune complex...Ch. 16.4 - Prob. 15ELOCh. 16.4 - Contrast type II and type III hypersensitivities...Ch. 16.4 - Explain what occurs in immune complex diseases and...Ch. 16.5 - Prob. 16ELOCh. 16.5 - Prob. 17ELOCh. 16.5 - Prob. 18ELOCh. 16.5 - Discuss the involvement of T cells in organ...Ch. 16.5 - Describe the categories of grafts and how...Ch. 16.5 - Prob. 22CYPCh. 16.5 - Prob. 23CYPCh. 16.5 - What does it mean to say that tissues from two...Ch. 16.5 - Prob. 25CYPCh. 16.6 - Prob. 21ELOCh. 16.6 - Explain the origins of autoimmunity and describe...Ch. 16.6 - Prob. 23ELOCh. 16.6 - Explain the pathologic process in autoimmunity.Ch. 16.6 - Prob. 27CYPCh. 16.6 - Describe four major types of autoimmunity,...Ch. 16.7 - Outline the categories of immunodeficiency...Ch. 16.7 - Prob. 25ELOCh. 16.7 - Relate examples of secondary immunodeficiencies.Ch. 16.7 - Describe the characteristics of cancer, and...Ch. 16.7 - Explain how immune function relates to the...Ch. 16.7 - Prob. 29CYPCh. 16.7 - Prob. 30CYPCh. 16.7 - Prob. 31CYPCh. 16.7 - Define cancer, and differentiate between a benign...Ch. 16.7 - Describe the relationship between cancer and the...Ch. 16.L1 - Prob. 1MCQCh. 16.L1 - Prob. 2MCQCh. 16.L1 - Which hypersensitivities are T-cell mediated? a....Ch. 16.L1 - The contact with allergen that results in symptoms...Ch. 16.L1 - Prob. 5MCQCh. 16.L1 - Prob. 6MCQCh. 16.L1 - Prob. 7MCQCh. 16.L1 - Prob. 8MCQCh. 16.L1 - Prob. 9MCQCh. 16.L1 - Prob. 10MCQCh. 16.L1 - Prob. 11MCQCh. 16.L1 - A positive tuberculin skin test is an example of...Ch. 16.L1 - Prob. 13MCQCh. 16.L1 - Prob. 14MCQCh. 16.L1 - Prob. 15MCQCh. 16.L1 - How is the immune system involved in development...Ch. 16.L1 - Pollen is which type of allergen? a. anti-a alone...Ch. 16.L1 - Prob. 2CSRCh. 16.L1 - Prob. 3CSRCh. 16.L1 - Compare and contrast atopic allerg and type IV...Ch. 16.L1 - Prob. 2WCCh. 16.L1 - Prob. 3WCCh. 16.L1 - Why is a hemolytic transfusion reaction considered...Ch. 16.L1 - Prob. 5WCCh. 16.L1 - Explain how people with autoimmunity could develop...Ch. 16.L2 - Suggest some possible physiological benefits of...Ch. 16.L2 - Prob. 2CTCh. 16.L2 - Why would a person be allergic to strawberries...Ch. 16.L2 - a. Where in the course of type I allergies do...Ch. 16.L2 - Prob. 5CTCh. 16.L2 - Prob. 6CTCh. 16.L2 - How can a person prevent becoming allergic to...Ch. 16.L2 - Prob. 8CTCh. 16.L2 - a. Explain why babies with agammaglobulinemia do...Ch. 16.L2 - In what ways can cancer be both a cause and a...Ch. 16.L2 - Looking at figure 15.8, reproduced here, explain...Ch. 16.L2 - Prob. 2VC
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