Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
11th Edition
ISBN: 9781259987304
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 16, Problem 5CT
Epinephrine is routinely mixed with local anesthetic solutions. Why?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
Ch. 16.1 - Describe the function of ANS.Ch. 16.1 - List the divisions of the ANS. Under what...Ch. 16.2 - Contrast the somatic nervous system with the ANS...Ch. 16.2 - Differentiate between preganglionic neurons and...Ch. 16.2 - Why are sensory neurons not classified as somatic...Ch. 16.3 - Where are the cell bodies of sympathetic...Ch. 16.3 - What types of axons (preganglionic or...Ch. 16.3 - Prob. 8AYPCh. 16.3 - Prob. 9AYPCh. 16.3 - Prob. 10AYP
Ch. 16.3 - Prob. 11AYPCh. 16.3 - Prob. 12AYPCh. 16.3 - Prob. 13AYPCh. 16.3 - Prob. 14AYPCh. 16.3 - Describe the lengths of the preganglionic and...Ch. 16.3 - From what are sympathetic autonomic nerve plexuses...Ch. 16.3 - Describe the four major ways by which sympathetic...Ch. 16.3 - Prob. 18AYPCh. 16.3 - Prob. 19AYPCh. 16.3 - Prob. 20AYPCh. 16.3 - Prob. 21AYPCh. 16.3 - Prob. 22AYPCh. 16.4 - Give two exceptions to the generalization that...Ch. 16.4 - Prob. 24AYPCh. 16.4 - Prob. 25AYPCh. 16.4 - Prob. 26AYPCh. 16.4 - Prob. 27AYPCh. 16.4 - Prob. 28AYPCh. 16.4 - Prob. 29AYPCh. 16.4 - In what two ways are adrenergic receptors...Ch. 16.5 - Describe the autonomic reflex that maintains blood...Ch. 16.5 - Prob. 32AYPCh. 16.5 - Prob. 33AYPCh. 16.6 - Prob. 34AYPCh. 16.6 - Prob. 35AYPCh. 16.6 - Prob. 36AYPCh. 16.6 - Prob. 37AYPCh. 16 - Given these phrases: (1) neuron cell bodies in the...Ch. 16 - Given these structures: (1) collateral ganglion...Ch. 16 - The white ramus communicans contains a....Ch. 16 - Prob. 4RACCh. 16 - Prob. 5RACCh. 16 - Prob. 6RACCh. 16 - Prob. 7RACCh. 16 - Which of these is not a part of the enteric...Ch. 16 - Sympathetic axons reach organs through all of the...Ch. 16 - Prob. 10RACCh. 16 - Prob. 11RACCh. 16 - Prob. 12RACCh. 16 - When acetylcholine binds to nicotinic receptors....Ch. 16 - Prob. 14RACCh. 16 - Prob. 15RACCh. 16 - Prob. 16RACCh. 16 - Prob. 17RACCh. 16 - Prob. 1CTCh. 16 - Prob. 2CTCh. 16 - Prob. 3CTCh. 16 - Prob. 4CTCh. 16 - Epinephrine is routinely mixed with local...Ch. 16 - Prob. 6CTCh. 16 - Prob. 7CTCh. 16 - Prob. 8CT
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