Laboratory Manual for Hole's Human Anatomy & Physiology Fetal Pig Version
15th Edition
ISBN: 9781260165418
Author: SHIER, David
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 16, Problem 28P
In what general ways do antibodies function?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Laboratory Manual for Hole's Human Anatomy & Physiology Fetal Pig Version
Ch. 16 - Prob. 1PCh. 16 - Prob. 2PCh. 16 - Prob. 3PCh. 16 - Prob. 4PCh. 16 - Prob. 5PCh. 16 - Prob. 6PCh. 16 - Prob. 7PCh. 16 - Prob. 8PCh. 16 - Prob. 9PCh. 16 - Prob. 10P
Ch. 16 - Prob. 11PCh. 16 - Prob. 12PCh. 16 - Why are the thymus and spleen considered organs of...Ch. 16 - Prob. 14PCh. 16 - Prob. 15PCh. 16 - Prob. 16PCh. 16 - Prob. 17PCh. 16 - Prob. 18PCh. 16 - Prob. 19PCh. 16 - Prob. 20PCh. 16 - Prob. 21PCh. 16 - Prob. 22PCh. 16 - Prob. 23PCh. 16 - Prob. 24PCh. 16 - Prob. 25PCh. 16 - Prob. 26PCh. 16 - Prob. 27PCh. 16 - In what general ways do antibodies function?Ch. 16 - Prob. 29PCh. 16 - What are the effects of complement activation?Ch. 16 - Prob. 31PCh. 16 - Prob. 32PCh. 16 - Prob. 33PCh. 16 - Prob. 34PCh. 16 - Prob. 35PCh. 16 - Prob. 36PCh. 16 - Prob. 37PCh. 16 - Prob. 1CACh. 16 - Prob. 2CACh. 16 - Prob. 3CACh. 16 - Explain why physical exercise promotes lymphatic...Ch. 16 - Prob. 5CACh. 16 - Prob. 6CACh. 16 - Prob. 7CACh. 16 - Prob. 8CACh. 16 - Prob. 9CACh. 16 - Prob. 10CACh. 16 - Compare and contrast the functions of the thymus...Ch. 16 - Prob. 12CACh. 16 - Prob. 13CACh. 16 - Prob. 14CACh. 16 - Prob. 15CACh. 16 - Prob. 16CACh. 16 - Prob. 17CACh. 16 - are specialized lymphocytes that secrete perforins...Ch. 16 - Prob. 19CACh. 16 - Prob. 20CACh. 16 - Prob. 21CACh. 16 - Prob. 22CACh. 16 - Define clone of lymphocytes. (p. 628)Ch. 16 - Prob. 24CACh. 16 - Prob. 25CACh. 16 - Prob. 26CACh. 16 - Prob. 27CACh. 16 - Prob. 28CACh. 16 - Prob. 29CACh. 16 - Prob. 30CACh. 16 - Prob. 31CACh. 16 - Prob. 32CACh. 16 - Prob. 33CACh. 16 - Prob. 34CACh. 16 - Prob. 35CACh. 16 - Prob. 36CACh. 16 - Prob. 37CACh. 16 - Prob. 38CACh. 16 - Prob. 39CACh. 16 - Prob. 40CACh. 16 - Prob. 41CACh. 16 - Prob. 42CACh. 16 - Prob. 43CACh. 16 - Prob. 44CACh. 16 - Prob. 45CACh. 16 - Prob. 46CACh. 16 - Prob. 47CACh. 16 - Why is injecting a substance into the skin like...Ch. 16 - Prob. 2IACh. 16 - Prob. 3IACh. 16 - Prob. 4IACh. 16 - Prob. 5IACh. 16 - Prob. 6IACh. 16 - 7. Why is a transplant consisting of fetal tissue...Ch. 16 - Prob. 8IA
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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