ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Kinetics: One-Compartment First-Order Absorption 1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration. Using this data and set of graphs, determine:(calculate for each variable) (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e)absolute ip bioavailability, Fip (f) absolute po bioavailability, Fpo

3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug: (a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate) (b) Estimate the time for maximum plasma concentration (tmax). (c) Estimate the maximum plasma concentration (Cmax). (d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.) (e)…

List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.

Answer 2

Question

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Answer 3

Question

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Answer 4

Question

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Answer 5

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Answer 6

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Answer 7

Chapter 15, Problem 3A

Summary Introduction

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Answer 8

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Answer 11

Ch. 15 - Compare pathogenicity with virulence.Ch. 15 - How are capsules and cell wall components related...Ch. 15 - Prob. 3R Ch. 15 - Explain how drugs that bind each of the following...Ch. 15 - Prob. 5R Ch. 15 - Prob. 6R Ch. 15 - Prob. 7R Ch. 15 - Which of the following genera is the most...Ch. 15 - How can viruses and protozoa avoid being killed by...Ch. 15 - Prob. 10R

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Solution Summary: The author analyzes how sulphonamides are effective for the salmonella's multiplication.

Concept explainers

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

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Chapter 15 Solutions

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Solution Summary: The author analyzes how sulphonamides are effective for the salmonella's multiplication.

Concept explainers

Introduction: ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.

Want to see the full answer?

Chapter 15 Solutions

Introduction:

ID 50 means INFETIOUS DOSE 50. This means number of micro-organisms is needed to infect the host. In laboratory the rats are injected with the prescribed dose of organism and they are examined. This salmonella obtains energy from oxidation and reduction reactions.