Biological Science (6th Edition)
Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 15, Problem 13PIAT

Ciprofloxacin inhibits DNA gyrase, a bacterial topoisomerase that cuts DNA ahead of the replication fork, winds the DNA in a direction that relieves the twists added during DNA synthesis, and then reseals the DNA. In ciprofloxacin-treated bacteria, newly synthesized DNA is found in fragments. Based on this evidence, what activity of DNA gyrase is likely to be inhibited by ciprofloxacin?

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