Biology: How Life Works
Biology: How Life Works
3rd Edition
ISBN: 9781319017637
Author: James Morris, Daniel Hartl, Andrew Knoll, Melissa Michael, Robert Lue, Andrew Berry, Andrew Biewener, Brian Farrell, N. Michele Holbrook
Publisher: Macmillan Higher Education
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Chapter 14.1, Problem 1SAQ
Summary Introduction

Nucleotides are building blocks of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). The nucleotide is composed of a nitrogenous base, sugar, and phosphate group. DNA is a genetic material, which consists of a long stretch of nucleotide sequences. DNA carries genetic information from mother to offspring in both prokaryotes and eukaryotes. Replication, transcription, and translation are important processes of the central dogma of biology. A change in the DNA sequence of the cell is known as a mutation. Mutations can affect the phenotype of an organism.

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY