HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 14, Problem 8WWWTS
Briefly explain why each of the following statements is false, or reword it to make it true.
8. The dermatomes are nonoverlapping regions of skin innervated by different spinal nerves.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
HUMAN ANATOMY
Ch. 14.1 - Prob. 1AWYKCh. 14.1 - Prob. 1BYGOCh. 14.1 - Prob. 2BYGOCh. 14.1 - Prob. 3BYGOCh. 14.1 - Prob. 4BYGOCh. 14.1 - Identify each of the following spinal tracts with...Ch. 14.2 - How does the structure of a nerve compare to that...Ch. 14.2 - Prob. 6BYGOCh. 14.2 - Prob. 7BYGOCh. 14.2 - List the five plexuses of spinal nerves and state...
Ch. 14.2 - State which plexus gives rise to each of the...Ch. 14.3 - Prob. 1AWYKCh. 14.3 - Prob. 10BYGOCh. 14.3 - Prob. 11BYGOCh. 14.3 - Describe a situation in which each of the...Ch. 14.4 - Prob. 1AWYKCh. 14.4 - Prob. 13BYGOCh. 14.4 - Prob. 14BYGOCh. 14.4 - Prob. 15BYGOCh. 14 - Four functions of the spinal cord and their...Ch. 14 - Prob. 14.1.2AYLOCh. 14 - Prob. 14.1.3AYLOCh. 14 - Prob. 14.1.4AYLOCh. 14 - Prob. 14.1.5AYLOCh. 14 - Prob. 14.1.6AYLOCh. 14 - Prob. 14.1.7AYLOCh. 14 - Prob. 14.1.8AYLOCh. 14 - The funiculi and tracts of spinal white matterCh. 14 - Prob. 14.1.10AYLOCh. 14 - Prob. 14.1.11AYLOCh. 14 - Prob. 14.1.12AYLOCh. 14 - Prob. 14.1.13AYLOCh. 14 - Prob. 14.2.1AYLOCh. 14 - The differences between afferent and efferent...Ch. 14 - Prob. 14.2.3AYLOCh. 14 - Prob. 14.2.4AYLOCh. 14 - The number of spinal nerves and the system for...Ch. 14 - The structure of the proximal portion of a spinal...Ch. 14 - Prob. 14.2.7AYLOCh. 14 - The five plexuses of spinal nerves-their names,...Ch. 14 - Prob. 14.3.1AYLOCh. 14 - The components of a reflex arc and the path...Ch. 14 - Prob. 14.3.3AYLOCh. 14 - The differences between ipsilateral,...Ch. 14 - Prob. 14.3.5AYLOCh. 14 - Prob. 14.4.1AYLOCh. 14 - Prob. 14.4.2AYLOCh. 14 - Prob. 14.4.3AYLOCh. 14 - Below L2, the vertebral canal is occupied by a...Ch. 14 - The brachial plexus gives rise to all of the...Ch. 14 - Prob. 3TYRCh. 14 - Prob. 4TYRCh. 14 - Prob. 5TYRCh. 14 - Prob. 6TYRCh. 14 - In the spinal cord, the neurosomas of the lower...Ch. 14 - Prob. 8TYRCh. 14 - Prob. 9TYRCh. 14 - Prob. 10TYRCh. 14 - Prob. 11TYRCh. 14 - Prob. 12TYRCh. 14 - Prob. 13TYRCh. 14 - Motor innervation of the leg proper comes...Ch. 14 - Prob. 15TYRCh. 14 - The _______ nerves arise from the servical plexus...Ch. 14 - The crossing of a nerve fiber actract from the...Ch. 14 - Prob. 18TYRCh. 14 - Prob. 19TYRCh. 14 - Prob. 20TYRCh. 14 - Prob. 1BYMVCh. 14 - Prob. 2BYMVCh. 14 - Prob. 3BYMVCh. 14 - Prob. 4BYMVCh. 14 - State a meaning of each word element and give a...Ch. 14 - Prob. 6BYMVCh. 14 - Prob. 7BYMVCh. 14 - Prob. 8BYMVCh. 14 - Prob. 9BYMVCh. 14 - Prob. 10BYMVCh. 14 - Prob. 1WWWTSCh. 14 - Prob. 2WWWTSCh. 14 - Prob. 3WWWTSCh. 14 - Briefly explain why each of the following...Ch. 14 - Prob. 5WWWTSCh. 14 - Prob. 6WWWTSCh. 14 - Prob. 7WWWTSCh. 14 - Briefly explain why each of the following...Ch. 14 - Prob. 9WWWTSCh. 14 - Briefly explain why each of the following...Ch. 14 - Prob. 1TYCCh. 14 - Prob. 2TYCCh. 14 - Anthony gets into a fight between rival gangs. As...Ch. 14 - When a patient needs a tendon graft, surgeons...
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