
Concept explainers
a.
To classify: The example of the increased sprinting performance of individuals with two different alleles of an actin gene, compared with individuals with two copies of just one of the alleles as frequency-dependent selection, heterozygote advantage, or clinical variation.
Introduction: Polymorphism refers to the occurrence of variation amongst the population. Polymorphism within a population maybe because of the three phenomenons: frequency-dependent selection, heterozygote advantage or clinical variation.
b.
To classify: The example of increased survival of individuals with rare color patterns, compared with those with common color patterns as frequency-dependent selection, heterozygote advantage, or clinical variation.
Introduction:
c.
To classify: The example of geographic variation in the size of deer from northern to southern latitudes as frequency-dependent selection, heterozygote advantage, or clinical variation
Introduction: Geographical variations are also an important factor contributing to the genetic variations. Different geographical spaces will give rise to different genotypes.

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Chapter 13 Solutions
PRINCIPLES OF LIFE
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- 50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forwardChoose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forward
- The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forwardWhat enzyme is necessary for synthesis of all of the monoamines?arrow_forward
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