Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 13, Problem 1TY

A mutation removes a single base pair within the coding sequence of a gene and inactivates the protein encoded by the gene. Such a mutation is

  1. a silent mutation.
  2. a missense mutation.
  3. a nonsense mutation.
  4. a frameshift mutation.
  5. both b and c.

Expert Solution & Answer
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Summary Introduction

Introduction:

The mutation can be described as a condition in which the nucleotide sequence of the DNA is altered. Even a single change in nucleotide may result in many consequences.

Answer to Problem 1TY

Option (d).

Explanation of Solution

Explanation for Correct Answer:

Option (d) frameshift mutation. The frameshift mutation occurs due to a deletion or insertion of nucleotide, which is not a multiple of 3. It causes the shifting of the entire reading frame of DNA sequence, which is the reason it is named so. Sometimes, frameshift mutation may cause deletion of a nucleotide and resulting in a premature presence of stop codon and terminate the sequence prior resulting in short polypeptide or inactivation of the gene product. Hence, it is the correct answer.

Explanation for the incorrect answer:

Option (a) silent mutation. The silent mutation results in the change of nucleotide but does not affect the amino acid or protein formed by that. Hence, it is an incorrect answer.

Option (b) missense mutation. The missense mutation is a mutation that results in the change of nucleotide and replaces the amino acid in the protein sequence, but the length of the sequence remains unaffected. Hence, it is an incorrect answer.

Option (c) nonsense mutation. The non-sense mutations can be described as point mutation which results in the occurrence of a premature stop codon due to the replacement of a nucleotide. In this mutation, the presence of stop codon before the end of the sequence result in early termination of the amino acid formation and result in shorter polypeptide. Hence, it is an incorrect answer.

Option (e) both (b) and (c). As both the option (b) and (c)are incorrect answers, this is also an incorrect option.

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Students have asked these similar questions
Suppose that a gene has a mutation that changes one nucleotide. Because of this one nucleotide change, the mRNA produced from this gene has a slightly different sequence compared to the mRNA produced from the unaltered/non-mutated gene. However, the resulting protein produced from both of these gene versions is exactly the same. This type of mutation would be classified as a missense mutation. degenerate mutation. silent mutation. nonsense mutation. frameshift mutation.
A nonsynonymous mutation is also referred to as missense mutation. Which of the following correctly describe these mutations? They are permanent and cannot revert or reverse mutate back into a wild-type sequence. They cause a non-functional amino acid to replace a functional amino acid. O They result in the insertion or deletion of a small number of nucleotides to the DNA. They change the nucleotide sequence of a gene but do not change the sequence of the resulting protein. None of the provided answers are correct. They convert a codon for a particular amino acid within a gene into a stop codon. They insert an additional amino acid into the final protein product.
Which of the following mutations would be most likely to have the most negative effect on the functioning of a protein produced by the gene? Group of answer choices a deletion of one nucleotide at the beginning of the coding sequence a substitution of one nucleotide at the beginning of the coding sequence an insertion of three nucleotides near the end of the coding sequence a substitution of one nucleotide near the end of the coding sequence
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