The following are suggested designs for group sequential studies. Using PROCSEQDESIGN, provide the following for the design O’Brien Fleming and Pocock.• The critical boundary values for each analysis of the data• The expected sample sizes at each interim analysisAssume the standardized Z score method for calculating boundaries.Investigators are evaluating the success rate of a novel drug for treating a certain type ofbacterial wound infection. Since no existing treatment exists, they have planned a one-armstudy. They wish to test whether the success rate of the drug is better than 50%, whichthey have defined as the null success rate. Preliminary testing has estimated the successrate of the drug at 55%. The investigators are eager to get the drug into production andwould like to plan for 9 interim analyses (10 analyzes in total) of the data. Assume thesignificance level is 5% and power is 90%.Besides, draw a combined boundary plot (OBF, POC, and HP)

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20 km, because GISS Worksheet 10 Jesse runs a small business selling and delivering mealie meal to the spaza shops. He charges a fixed rate of R80, 00 for delivery and then R15, 50 for each packet of mealle meal he delivers. The table below helps him to calculate what to charge his customers. 10 20 30 40 50 Packets of mealie meal (m) Total costs in Rands 80 235 390 545 700 855 (c) 10.1. Define the following terms: 10.1.1. Independent Variables 10.1.2. Dependent Variables 10.2. 10.3. 10.4. 10.5. Determine the independent and dependent variables. Are the variables in this scenario discrete or continuous values? Explain What shape do you expect the graph to be? Why? Draw a graph on the graph provided to represent the information in the table above. TOTAL COST OF PACKETS OF MEALIE MEAL 900 800 700 600 COST (R) 500 400 300 200 100 0 10 20 30 40 60 NUMBER OF PACKETS OF MEALIE MEAL