HUMAN ANATOMY PKG >CUSTOM<
8th Edition
ISBN: 9781323572528
Author: Marieb
Publisher: Pearson Custom Publishing
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Chapter 12, Problem 2CRCAQ
An MRI scan and other diagnostic tests indicated that Laressa had developed an
oligodendroglioma. Can you deduce from its name what an oligodendroglioma is?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 12 Solutions
HUMAN ANATOMY PKG >CUSTOM<
Ch. 12 - In which direction are afferent signals carried?...Ch. 12 - What subdivision of the nervous system regulates...Ch. 12 - What type of sensation is (a) pain from a pulled...Ch. 12 - Which type of neuron process receives stimuli?Ch. 12 - Describe how the electrical impulse from one...Ch. 12 - What is the structural type of most sensory...Ch. 12 - Which structural type of neuron is most abundant?...Ch. 12 - Which neuroglia make myelin in the CNS? In the...Ch. 12 - Which neuroglia are common in regions where...Ch. 12 - Do Schwann cells cover nonmyelinated axons in the...
Ch. 12 - Name the connective tissue wrapping that encloses...Ch. 12 - Where do synaspes occur in the CNS, in white...Ch. 12 - Why is white matter white?Ch. 12 - If there is no interneuron in a reflex arc, as in...Ch. 12 - If you touch a hot stove, you reflexively...Ch. 12 - What type of neuronal circuit contains multiple...Ch. 12 - Both peripheral nerves and the white matter of the...Ch. 12 - From your understanding of the functions of myelin...Ch. 12 - What type of neurons form from neuroblasts in the...Ch. 12 - How does the development of sensory neurons...Ch. 12 - Which of the following structures is not part of...Ch. 12 - Match the names of the cells in column B with the...Ch. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - An example of an effector is (a) the eye, (b) a...Ch. 12 - Prob. 6RQCh. 12 - A ganglion is a collection of (a) neuron cell...Ch. 12 - A synapse between a terminal bouton and a neuron...Ch. 12 - Myelin is most like which of the following cell...Ch. 12 - Prob. 10RQCh. 12 - Afferent neurons of the PNS synapse in the CNS...Ch. 12 - Prob. 12RQCh. 12 - Prob. 13RQCh. 12 - Place the connective tissue coverings surrounding...Ch. 12 - Define proprioception.Ch. 12 - Prob. 16RQCh. 12 - Prob. 17RQCh. 12 - Distinguish gray matter from white matter of the...Ch. 12 - What is distinctive about the appearance of a cell...Ch. 12 - Describe the differences between neurons and...Ch. 12 - Distinguish a nerve from a nerve fiber and a...Ch. 12 - Prob. 22RQCh. 12 - Draw a reflex arc in place in the nervous system...Ch. 12 - Prob. 24RQCh. 12 - Why are the cell bodies of sensory neurons located...Ch. 12 - Prob. 26RQCh. 12 - Two anatomists were arguing about a sensory...Ch. 12 - An MRI scan and other diagnostic tests indicated...Ch. 12 - Prob. 3CRCAQCh. 12 - Rochelle developed multiple sclerosis when she was...Ch. 12 - Reflexes can be somatic (as in the knee-jerk...Ch. 12 - Prob. 6CRCAQ
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