EBK BIOLOGY
EBK BIOLOGY
11th Edition
ISBN: 9780134226453
Author: Byers
Publisher: PEARSON
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Book Icon
Chapter 12, Problem 1MC

If a parental DNA strand has the base sequence A-T-T-G-C-A-C-T, DNA polymerase would synthesize a new strand with the sequence

a. A-T-T-G-C-A-C-T.

b. T-A-A-C-G-T-G-A.

c. C-G-G-T-A-C-A-G.

d. The sequence of the new strand cannot be determined from the information given.

Expert Solution & Answer
Check Mark
Summary Introduction

Introduction:

Deoxyribonucleic acid (DNA) carrying the genetic information, is a double-helical structure. At the time of the replication, two strands of the DNA unwound from each other. The sole purpose of this mechanism is for the formation of the new strands which are complementary to each other. This is also known as Chargaff’s rule.

Answer to Problem 1MC

Correct answer:

According to the base pairing rule, if a parental DNA strand has A-T-T-G-C-A-C-T base sequence, its complementary strand will be formed having a T-A-A-C-G-T-G-A base sequence.

Explanation of Solution

Explanation for the correct statement:

Option (b) is given as, T-A-A-C-G-T-G-A. The formation of the new strands follows the complementarity rule. This states that A (adenine) will always pair with T (thymine) with a double bond whereas, G (guanine) will always pair with C (cytosine) with a triple bond. According to this rule, option (b) is correct.

Explanation for incorrect answers:

Option (a) is given as, A-T-T-G-C-A-C-T. Pairing either purine with purine or pyrimidine with a pyrimidine, imparts a strong repelling force thereby, hampering in the hydrogen bond formation between the bases. So, it is an incorrect answer.

Option (c) is given as, C-G-G-T-A-C-A-G. Formation of bonds depends upon the specific structure of the bases which allows them to form the hydrogen bond between them. Adenine shares only two atoms for the bond formation, which only welcomes thymine with its two atoms for the same. So, it is an incorrect answer.

Option (d) is given as the sequence of the new strand cannot be determined from the information given. Once the information about the bases is provided from one strand, it is possible to retrieve the other strand’s bases via Chargaff’s rule. As per the rule, A will always pair with T by two hydrogen bonds and G will always pair with C with three hydrogen bonds. So, it is an incorrect answer.

Hence, option (a), (c), and (d) are incorrect.

Conclusion

Therefore, it can be concluded that the retrieval of the other strand information at the time of replication is easy and useful. Once the information is provided about either of the strands, the further process can be studied with the help of complementary rule.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Students have asked these similar questions
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
Biology
ISBN:9781305967359
Author:STARR
Publisher:CENGAGE L
Text book image
Concepts of Biology
Biology
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:OpenStax College
Text book image
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Essentials of Pharmacology for Health Professions
Nursing
ISBN:9781305441620
Author:WOODROW
Publisher:Cengage
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY