Probability and Statistics for Engineers and Scientists
9th Edition
ISBN: 9780321629111
Author: Ronald E. Walpole, Raymond H. Myers, Sharon L. Myers, Keying Ye
Publisher: Prentice Hall
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Chapter 11.6, Problem 22E
To determine
Find the 95% confidence interval for
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Secondary Analysis with Generalized Linear Mixed Model with clustering for Hospital Center and ICUvs Ward EnrolmentIn a secondary adjusted analysis we used generalized linear mixed models with random effects forcenter (a stratification variable in the primary analyses). In this analysis, the relative risk for the primaryoutcome of 90-day mortality for 7 versus 14 days of antibiotics was 0.90 (95% Confidence Interval [CI]0.78, 1.05).
In a crossover trial comparing a new drug to a standard, π denotes the probabilitythat the new one is judged better. It is desired to estimate π and test H0 : π = 0.5against H1 : π = 0.5. In 20 independent observations, the new drug is better eachtime.(a) Find and plot the likelihood function. Give the ML estimate of π (Hint: youmay use the plot function in R)
Can you explain what this analysis means in layman's terms?
- We calculated that a target sample size of 3626, which was based on anticipated baseline 90-day mortality of 22% and a noninferiority margin of no more than 4 percentage points, would give the trial 80% power, at a one-sided alpha level of 2.5%, accounting for a maximum of 5% loss to follow-up and for early stopping rules for three interim analyses.-
Chapter 11 Solutions
Probability and Statistics for Engineers and Scientists
Ch. 11.3 - A study was conducted at Virginia Tech to...Ch. 11.3 - The grades of a class of 9 students on a midterm...Ch. 11.3 - The amounts of a chemical compound y that...Ch. 11.3 - The following data were collected to determine the...Ch. 11.3 - A study was made on the amount of converted sugar...Ch. 11.3 - In a certain type of metal test specimen, the...Ch. 11.3 - The following is a portion of a classic data set...Ch. 11.3 - Prob. 8ECh. 11.3 - Prob. 9ECh. 11.3 - Prob. 10E
Ch. 11.3 - The thrust of an engine (y) is a function of...Ch. 11.3 - Prob. 12ECh. 11.3 - A study of the amount of rainfall and the quantity...Ch. 11.3 - Prob. 14ECh. 11.6 - With reference to Exercise 11.1 on page...Ch. 11.6 - Prob. 16ECh. 11.6 - Prob. 17ECh. 11.6 - Prob. 18ECh. 11.6 - Prob. 19ECh. 11.6 - Prob. 20ECh. 11.6 - Prob. 21ECh. 11.6 - Prob. 22ECh. 11.6 - Prob. 23ECh. 11.6 - Prob. 25ECh. 11.6 - Prob. 26ECh. 11.6 - Prob. 27ECh. 11.6 - Prob. 28ECh. 11.6 - Prob. 29ECh. 11.6 - Prob. 30ECh. 11.9 - Prob. 31ECh. 11.9 - Prob. 32ECh. 11.9 - Prob. 33ECh. 11.9 - Prob. 34ECh. 11.9 - Prob. 35ECh. 11.9 - Prob. 36ECh. 11.9 - Prob. 37ECh. 11.9 - Prob. 38ECh. 11.9 - A regression model is desired relating temperature...Ch. 11.9 - Prob. 40ECh. 11.9 - Prob. 41ECh. 11.9 - Prob. 42ECh. 11.12 - Prob. 43ECh. 11.12 - Prob. 44ECh. 11.12 - Prob. 45ECh. 11.12 - Prob. 46ECh. 11.12 - Prob. 47ECh. 11.12 - With reference to Exercise 11.8 on page 399,...Ch. 11.12 - Prob. 49RECh. 11.12 - Prob. 50RECh. 11.12 - Prob. 51RECh. 11.12 - Prob. 52RECh. 11.12 - Prob. 53RECh. 11.12 - Prob. 54RECh. 11.12 - Prob. 55RECh. 11.12 - Prob. 56RECh. 11.12 - Prob. 57RECh. 11.12 - Prob. 58RECh. 11.12 - Prob. 59RECh. 11.12 - Prob. 60RECh. 11.12 - Prob. 61RECh. 11.12 - Prob. 62RECh. 11.12 - Prob. 63RECh. 11.12 - Prob. 64RECh. 11.12 - Prob. 65RECh. 11.12 - Prob. 66RECh. 11.12 - Prob. 67RE
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