ANATOMY & PHYSIOLOGY LL\AC
9th Edition
ISBN: 9781264325948
Author: SALADIN
Publisher: MCG
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Textbook Question
Chapter 1.1, Problem 3AYLO
Branches of anatomy that study the body at different levels of detail
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
ANATOMY & PHYSIOLOGY LL\AC
Ch. 1.1 - What is the difference between anatomy and...Ch. 1.1 - Name the method that would be used for each of the...Ch. 1.1 - The meanings of anatomy and physiology and what it...Ch. 1.1 - Prob. 2AYLOCh. 1.1 - Branches of anatomy that study the body at...Ch. 1.1 - How comparative physiology advances the...Ch. 1.2 - In what way did the followers of Galen disregard...Ch. 1.2 - Prob. 4BYGOCh. 1.2 - How is our concept of human form and function...Ch. 1.2 - Greek and Roman scholars who first gave medicine a...
Ch. 1.2 - Prob. 2AYLOCh. 1.2 - Why medical science today owes such a great debt...Ch. 1.2 - How Schleiden and Schwann revolutionized and...Ch. 1.3 - Describe the general process involved in the...Ch. 1.3 - Describe some sources of potential bias in...Ch. 1.3 - Is there more information in an individual...Ch. 1.3 - How philosophers Bacon and Descartes...Ch. 1.3 - Prob. 2AYLOCh. 1.3 - Prob. 3AYLOCh. 1.3 - The qualities of a valid scientific hypothesis,...Ch. 1.3 - How each of the following contributes to the...Ch. 1.3 - The distinctions between scientific facts, laws,...Ch. 1.4 - Define adaptation and selection pressure. Why are...Ch. 1.4 - Prob. 10BYGOCh. 1.4 - Select two other human characteristics and explain...Ch. 1.4 - The meanings of evolution, natural selection,...Ch. 1.4 - The historical origin of the theory of natural...Ch. 1.4 - How the kinship among all species is relevant to...Ch. 1.4 - Ecological conditions thought to have selected for...Ch. 1.4 - Prob. 5AYLOCh. 1.5 - Prob. 12BYGOCh. 1.5 - Prob. 13BYGOCh. 1.5 - Why is reductionism a necessary out not sufficient...Ch. 1.5 - Prob. 15BYGOCh. 1.5 - Prob. 1AYLOCh. 1.5 - Prob. 2AYLOCh. 1.5 - Examples of why the anatomy presented in textbooks...Ch. 1.6 - List four Etiological criteria of life and one...Ch. 1.6 - What is meant by dynamic equilibrium? Why would it...Ch. 1.6 - Prob. 18BYGOCh. 1.6 - Explain why positive feedback is more likely than...Ch. 1.6 - Prob. 20BYGOCh. 1.6 - Eight essential qualities that distinguish living...Ch. 1.6 - Prob. 2AYLOCh. 1.6 - Prob. 3AYLOCh. 1.6 - The clinical importance of physiological variation...Ch. 1.6 - Prob. 5AYLOCh. 1.6 - Prob. 6AYLOCh. 1.6 - Prob. 7AYLOCh. 1.6 - The concept of matter and energy flowing down...Ch. 1.7 - Explain why modern anatomical terminology is so...Ch. 1.7 - Distinguish between an eponym and an acronym, and...Ch. 1.7 - Prob. 23BYGOCh. 1.7 - Prob. 24BYGOCh. 1.7 - Prob. 1AYLOCh. 1.7 - How to break biomedical terms into familiar roots,...Ch. 1.7 - Prob. 3AYLOCh. 1.7 - Prob. 4AYLOCh. 1.7 - Why precision in spelling and usage of medical...Ch. 1.8 - A description of six core themes of this book:...Ch. 1 - Prob. 1TYRCh. 1 - Prob. 2TYRCh. 1 - The simplest structures considered to be alive are...Ch. 1 - Which of the following people revolutionized the...Ch. 1 - Which of the following embodies the greatest...Ch. 1 - Prob. 6TYRCh. 1 - A self-amplifying chain of physiological events is...Ch. 1 - Which of the following is not a human organ...Ch. 1 - ______ means studying anatomy by touch. a. Gross...Ch. 1 - The prefix hetero- means a. same. b. different. c....Ch. 1 - Cutting and separating tissues to reveal...Ch. 1 - A difference in chemical concentration between one...Ch. 1 - Prob. 13TYRCh. 1 - Physiological effects of a persons mental state...Ch. 1 - The tendency of the body to maintain stable...Ch. 1 - Blood pH averages 7.4 but fluctuates from 7.35 to...Ch. 1 - Prob. 17TYRCh. 1 - Prob. 18TYRCh. 1 - Prob. 19TYRCh. 1 - Prob. 20TYRCh. 1 - Prob. 1BYMVCh. 1 - Prob. 2BYMVCh. 1 - Prob. 3BYMVCh. 1 - metabolo-Ch. 1 - Prob. 5BYMVCh. 1 - physio-Ch. 1 - Prob. 7BYMVCh. 1 - Prob. 8BYMVCh. 1 - Prob. 9BYMVCh. 1 - tomo-Ch. 1 - Prob. 1WWTSCh. 1 - Prob. 2WWTSCh. 1 - Prob. 3WWTSCh. 1 - Prob. 4WWTSCh. 1 - Matter does not generally move down a gradient in...Ch. 1 - Prob. 6WWTSCh. 1 - Prob. 7WWTSCh. 1 - Prob. 8WWTSCh. 1 - Human evolution is basically a theory that humans...Ch. 1 - Prob. 10WWTSCh. 1 - Ellen is pregnant and tells Janet, one of her...Ch. 1 - Which of the characteristics of living things are...Ch. 1 - About 1 out of every 120 live-born infants has a...Ch. 1 - How might human anatomy be different today if the...Ch. 1 - Prob. 5TYC
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