Campbell Biology in Focus
3rd Edition
ISBN: 9780134710679
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Rebecca Orr
Publisher: PEARSON
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Chapter 11, Problem 14TYU
Imagine that you are a genetic counselor, and a couple planning to start a family comes to you for information. Charles was married once before, and he and his first wife had a child with cystic fibrosis. The brother of his current wife, Elaine, died of cystic fibrosis. What is the probability that Charles and Elaine will have a baby with cystic fibrosis? (Neither Charles, nor Elaine, nor their parents have cystic fibrosis.)
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A woman knows that her mother is a carrier of Kartagener’s syndrome (an autosomal recessive disorder). The woman does not know if either she or her husband are carriers. The couple wants to have a child, but is worried about whether or not they could have a child with Kartagener’s syndrome. Should the couple seek the advice of a genetic counselor? In other words, is there a chance they could have an affected child? If there is a chance, please make sure your answer includes the specific parental genotypes necessary to make this possible.
Answer the second question? About pros and cons
Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF.
a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF?
b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected?
c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
Chapter 11 Solutions
Campbell Biology in Focus
Ch. 11.1 - DRAW IT Pea plants heterozygous for flower...Ch. 11.1 - List all gametes that could be made by a pea plant...Ch. 11.1 - Prob. 3CCCh. 11.2 - For any gene with a dominant allele A and...Ch. 11.2 - Two organisms, with genotypes BbDD and BBDd, are...Ch. 11.2 - Prob. 3CCCh. 11.3 - Incomplete dominance and epistasis are both terms...Ch. 11.3 - Prob. 2CCCh. 11.3 - WHAT IF? A rooster with gray feathers and a hen of...Ch. 11.4 - Lucia and Jared each have a sibling with cystic...
Ch. 11.4 - MAKE CONNECTIONS In Table 11.1, note the...Ch. 11 - DRAW IT Two pea plants heterozygous for the...Ch. 11 - A man with type A blood marries a woman with type...Ch. 11 - A man has six fingers on each hand and six toes on...Ch. 11 - Prob. 4TYUCh. 11 - Flower position, stem length, and seed shape are...Ch. 11 - Prob. 6TYUCh. 11 - Prob. 7TYUCh. 11 - Prob. 8TYUCh. 11 - Prob. 9TYUCh. 11 - Prob. 10TYUCh. 11 - In tigers, a recessive allele that is pleiotropic...Ch. 11 - Prob. 12TYUCh. 11 - Prob. 13TYUCh. 11 - Imagine that you are a genetic counselor, and a...Ch. 11 - Prob. 15TYUCh. 11 - Prob. 16TYUCh. 11 - Prob. 17TYUCh. 11 - Prob. 18TYU
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- You met with two parents whose first child has sickle cell anemia. (The parents show no signs of the disease themselves). The mother comes to you in the third month of her second pregnancy, and wants to know if this child will also inherit the disease. As a genetics counselor, you are ready to evaluate this couple’s case by doing the following:1. Determine what the genotype of each parent is. Is this disease autosomal or sex-linked? Dominant or recessive?arrow_forwardAs a genetic counselor, you inform Susan and John that a blood test for cystic fibrosis is available. Would you recommend genetic testing for Susan and John? Explain.arrow_forwardGeneticists are concerned about three different genetic conditions present within their family. Achondroplasia is an autosomal dominant genetic disorder that results in short-limbed dwarfism. (A = achondroplasia allele; a = average height allele). Red-Green Color blindness is an X-linked recessive genetic disorder (Xc = color blindness allele; XC = normal color vision allele). The 7-year-old son has an autosomal recessive form of deafness. (h = deafness allele; H = normal hearing allele.) All three family members were karyotyped, and additional genetic testing was performed to determine the chromosomal location of the genes being studied. The figures below show the karyotypes of the mother and father with respect to the chromosomes containing the three genes mentioned above. Question: The couple’s 7-year-old son has all three of these genetic conditions (achondroplasia, color blindness and deafness). Taking into consideration the genotypes of his parents, what is the complete…arrow_forward
- In man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?arrow_forwardLauren has chronic bronchitis and frequently ends up hospitalized with pneumonia. She has no family history of cystic fibrosis, a serious recessive genetic disorder which affects respiratory and digestive tracts. She and her husband Nat have one child after undergoing fertility treatments to overcome Nat's infertility. They are surprised when their child is diagnosed with cystic fibrosis and the genetic counselor tells them that they each also have the condition, which causes their bronchitis and infertility. Which of the following would be a reasonable explanation of their situation? Although the underlying disease is genetic, the severity of the disorder if influenced by environmental variation. Cystic fibrosis displays variable expressivity. There are different alleles of cystic fibrosis which cause differing forms of the disease. There are different alleles of cystic fibrosis which cause differing forms of the disease and Cystic fibrosis displays variable expressivity are the only…arrow_forwardYOUR SISTER DIED FROM TAY-SACHS DISEASE, INHERITED AS A RECESSIVE ALLELE (t). you're married and planning to start your family. you're worried about the disease and decide to have genetic testing to see if you or your spouse is a carrier of the tay-sachs allele. the test results show that you're a carrier of the allele, but your spouse isn't. what is the probability that you and your spouse will have a child with tay-sachs disease? show your work.arrow_forward
- Divya is 32 years old. She has found a small lump in her left breast and decided to go to her GP for a check-up. Her GP examined her and asked whether terse was any family history of cancer. She said her sister had breast cancer and he mother had died of ovarian cancer. Divya said there were also cases of cancer within her extended family. The pedigree below shows 3 generations of Divya’s family. The GP analysed the pedigree and concluded there was likely to be an inherited mutation running through Divya’s family and immediately referred her for a mammogram and a biopsy of the lump. Tissue from the biopsy was set for gene testing. Part 1 What type of inherited cancer syndrome appears to be present in Divya’s family? Part 2 What is the name of the gene being tested for matrons and what gene class does it belong to? Part 3 Are inherited mutations in this gene loss of function, gain of function or silent? Would you expect an individual to inherit a mutation in both parental copies of this…arrow_forwardCystic fibrosis in humans is caused by mutations in a single gene and is inherited as an autosomal (non-sex chromosome) recessive trait. An unaffected couple has two children. The first child has cystic fibrosis, and the second child is unaffected. What is the probability that the second child is a carrier (heterozygous) for the mutation that causes the disease? 2/3 1 1/2 3/4arrow_forwardLois, who recently had her karyotype performed, was shown the following figure from her family physician. Lois does not suffer or show any signs of any genetic condition. Peter Lois A. What type of abnormality is shown in Lois' karyotype and explain why she does not have a genetic condition? B. Lois and Peter are expecting their 1st child. What is the probabilitv that the child will have a genetic condition due to the translocation? Show your workarrow_forward
- The next four questions are all related to this problem: Polydactyly (PD) is an autosomal dominant trait (polydactyly - P; wildtype - p). Cystic fibrosis (CF) is an autosomal recessive trait (cystic fibrosis - f; wildtype - F). A PD woman, otherwise normal in phenotype, marries a healthy normal man. Their 4 children are: 1) normal, 2) PD, 3) CF, 4) CF + PD. You will walk through a series of steps to answer this question: What is the probability that their 5th child will have at least one of these conditions? Here is the first step: 1. What is the cross? (Hint: You can use the 4 existing children to determine the genotypes of the parents.) O PpFF (female) x ppFF (male) O PoFf (female) x ppft (male) O pof female) x PPFI (male) O PPFF Ifemale) x ppFf (male) 2. What is/are the target genotypes? O pof OP.F. O pott O P.M 3. What is the probability the child will have PD AND cystic fibrosis? Answer to two decimal places (eg. 0.88). 4. What is the probability that their 5th child will have at…arrow_forwardAnnabeth and Percy are concerned about having a child with Niemann - Pick disease, which causes abnormal accumulation of fat in cells. This condition, which is very rare, has affected Annabeth's niece (her brother's daughter) and Percy's aunt (his father's sister ). No one else in either family has the condition. What is the probability Annabeth and Percy's first child will have the disease? What is the probability Annabeth and Percy's first child will have the disease? 1/64 1/32 1/24 1/18 1/12 1/9 1/4 None of these abovearrow_forwardA recently married couple are both heterozygous for cystic fibrosis, a recessive genetic disorder. They would like to start a family and would like to have two children. a.) What is the probability that their second pregnancy would result in a child with cystic fibrosis? b.) What is the probability that their second pregnancy would result in a child with cystic fibrosis?arrow_forward
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