Chemistry (OER)
19th Edition
ISBN: 9781947172623
Author: OpenStax
Publisher: OpenStax College
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Textbook Question
Chapter 10, Problem 70E
Classify each substance in the table as either a metallic, ionic, molecular, or covalent network solid:
| Substance | Appearance | Melting Point | Electrical Conductivity | Solubility in Water |
| X | lustrous, malleable | 1500 °C | high | insoluble |
| Y | Soft, yellow | 113 °C | None | Insoluble |
| Z | Hard, white | 800 °C | Only if melted/dissolved | soluble |
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Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
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Chapter 10 Solutions
Chemistry (OER)
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