ANATOMY & PHYSIOLOGY 4/E PAC 1 SEMESTER
4th Edition
ISBN: 9781265061173
Author: McKinley
Publisher: MCG CUSTOM
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Textbook Question
Chapter 10, Problem 2CSL
Describe the effect of the botulinum toxin, which inhibits the release of acetylcholine at the neuromuscular junction. Would the poison curare, which competes for acetylcholine receptors have a similar effect? Explain
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 10 Solutions
ANATOMY & PHYSIOLOGY 4/E PAC 1 SEMESTER
Ch. 10.1 - What are the five major functions of skeletal...Ch. 10.1 - Prob. 2WDYLCh. 10.2 - Prob. 3WDYLCh. 10.2 - Draw and label a diagram of a sarcomere.Ch. 10.2 - Prob. 5WDYLCh. 10.2 - Prob. 6WDYLCh. 10.2 - Diagram and label the anatomic structures of a...Ch. 10.2 - Prob. 8WDYLCh. 10.3 - What triggers the binding of synaptic vesicles to...Ch. 10.3 - What two events are linked in the physiologic...
Ch. 10.3 - Prob. 11WDYLCh. 10.3 - Prob. 12WDYLCh. 10.3 - Describe the four processes that repeat in...Ch. 10.3 - What causes the release of the myosin head from...Ch. 10.3 - How do acetylcholinesterase and Ca2+ pumps...Ch. 10.4 - Prob. 16WDYLCh. 10.4 - What are the various means for making ATP...Ch. 10.4 - Prob. 18WDYLCh. 10.5 - Prob. 19WDYLCh. 10.5 - Prob. 20WDYLCh. 10.5 - Prob. 21WDYLCh. 10.6 - What events are occurring in a muscle that produce...Ch. 10.6 - What is recruitment? Explain its importance in the...Ch. 10.6 - Prob. 24WDYLCh. 10.7 - What is the function of skeletal muscle tone?Ch. 10.7 - When you flex your biceps brachii while doing...Ch. 10.7 - Prob. 27WDYLCh. 10.7 - How can muscle fatigue result from changes in each...Ch. 10.8 - Prob. 29WDYLCh. 10.8 - Prob. 30WDYLCh. 10.9 - What are three anatomic or physiologic differences...Ch. 10.10 - Prob. 32WDYLCh. 10.10 - Prob. 33WDYLCh. 10.10 - Prob. 34WDYLCh. 10.10 - What are the steps of smooth muscle contraction?Ch. 10.10 - What unique characteristics of smooth muscle allow...Ch. 10.10 - Prob. 37WDYLCh. 10.10 - Prob. 38WDYLCh. 10.10 - Prob. 39WDYLCh. 10 - Prob. 1DYKBCh. 10 - The physiologic event that takes place at the...Ch. 10 - In a skeletal muscle fiber, Ca2+ is released from...Ch. 10 - The bundle of dense regular connective tissue that...Ch. 10 - In excitation-contraction coupling, the transverse...Ch. 10 - During muscle contraction, the I band a. hides the...Ch. 10 - During a concentric contraction of a muscle fiber,...Ch. 10 - What event causes a troponin-tropomyosin complex...Ch. 10 - In sustained, moderate exercise, skeletal muscle...Ch. 10 - Skeletal muscle and cardiac muscle are similar in...Ch. 10 - Explain the structural relationship between a...Ch. 10 - Prob. 12DYKBCh. 10 - Prob. 13DYKBCh. 10 - Put the following skeletal muscle contraction...Ch. 10 - Explain the various means of providing ATP for...Ch. 10 - Explain why athletes who excel at short sprints...Ch. 10 - Explain why skeletal muscle generates the most...Ch. 10 - Prob. 18DYKBCh. 10 - Describe the response of smooth muscle to...Ch. 10 - Prob. 20DYKBCh. 10 - Prob. 1CALCh. 10 - One of the primary reasons that one individual is...Ch. 10 - Prob. 3CALCh. 10 - Rigor mortis occurs following death because a....Ch. 10 - Prob. 5CALCh. 10 - Prob. 1CSLCh. 10 - Describe the effect of the botulinum toxin, which...Ch. 10 - Smooth muscle is within the urinary bladder wall....
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