Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 10, Problem 1Q
Microbial resistance to drugs is acquired through
- a. conjugation.
- b. transformation.
- c. transduction.
- d. all of these.
Expert Solution & Answer
Summary Introduction
Introduction:
Many antibiotics are natural products of fungi and bacteria; therefore, microbes have developed a survival strategy involving resistance to these antibiotics. There are some ways in which microbes acquire antimicrobial resistance, whether antibiotics are present or not.
Answer to Problem 1Q
Correct answer:
Microbial resistance to drugs is acquired through conjugation, transduction, and transformation. Therefore, option (d) is correct.
Option (d) is given as “all of these”
Explanation of Solution
Justify reasons for the correct statement:
One of the main ways in which microbes can acquire antimicrobial resistance is by acquisition of entire new genes or sets of genes via horizontal transfer from another species. This mode begins with plasmids, which are transferred via conjugation, transduction, or transformation. Genes in chromosomes, along with plasmids that contain codes for resistance to drugs can also be replicated to be inherited by successive progenies. This mode leads to emergence of a drug resistance species.
Justify reasons for the incorrect statements:
Option (a) is given as “conjugation”.
Microbial resistance to drugs is acquired through conjugation, transduction, and transformation. Hence, it is a wrong answer.
Option (b) is given as “transformation”.
Only transformation is not sufficient for microbes to acquire resistance to drugs; process of transduction and conjugation are also required. Hence, it is a wrong answer.
Option (c) is given as “transduction”.
Just transduction does not sufficient to microbial resistance to drugs; process of transformation and conjugation are also required. Hence, it is a wrong answer.
Hence, options (a), (b), and (c) are incorrect.
Conclusion
Microbial plasmids are transferred via conjugation, transduction, or transformation to other microbes for the acquisition of resistance to drugs. Genes in plasmids that contain codes for resistance to drugs can also be replicated to be inherited by successive progenies.
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Chapter 10 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 10.1 - State the main goal of antimicrobial treatment.Ch. 10.1 - Identify the sources for the most commonly used...Ch. 10.1 - Describe two methods for testing antimicrobial...Ch. 10.1 - Prob. 4AYPCh. 10.1 - NCLEX PREP 1. An RN is caring for a 26-year-old...Ch. 10.2 - Explain the concept of selective toxicity.Ch. 10.2 - List the five major targets of antimicrobial...Ch. 10.2 - Prob. 7AYPCh. 10.2 - Distinguish between broad-spectrum and...Ch. 10.2 - Prob. 9AYP
Ch. 10.2 - Explain the mode of action of penicillinases and...Ch. 10.2 - Identify two antimicrobials that act by inhibiting...Ch. 10.2 - Prob. 12AYPCh. 10.2 - Identify one example of a fluoroquinolone.Ch. 10.2 - Describe the mode of action of drugs that target...Ch. 10.2 - Prob. 15AYPCh. 10.2 - Prob. 16AYPCh. 10.2 - Explain why antiprotozoal and antihelminthic drugs...Ch. 10.2 - List the three major targets of action of...Ch. 10.2 - Prob. 2NPCh. 10.3 - Discuss two main ways that microbes acquire...Ch. 10.3 - List five cellular or structural mechanisms that...Ch. 10.3 - Prob. 21AYPCh. 10.3 - Prob. 3NPCh. 10.3 - Prob. 1MMCh. 10.4 - Distinguish between drug toxicity and allergic...Ch. 10.4 - Prob. 23AYPCh. 10.4 - Prob. 4NPCh. 10.4 - Prob. 5NPCh. 10 - Microbial resistance to drugs is acquired through...Ch. 10 - Prob. 2QCh. 10 - Prob. 3QCh. 10 - Prob. 4QCh. 10 - Why does the penicillin group of antibiotics have...Ch. 10 - Prob. 6QCh. 10 - Prob. 7QCh. 10 - Conduct research to find out why drugs blocking...Ch. 10 - Prob. 9QCh. 10 - Prob. 10QCh. 10 - You take a sample from a growth-free portion of...Ch. 10 - Prob. 12QCh. 10 - Treating malarial infections is theoretically...Ch. 10 - Can you think of a situation in which it would be...Ch. 10 - Prob. 15QCh. 10 - Prob. 16QCh. 10 - Prob. 17QCh. 10 - Prob. 18QCh. 10 - An antimicrobial drug with a _______ therapeutic...Ch. 10 - Prob. 20QCh. 10 - Prob. 21QCh. 10 - Prob. 1VC
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