Vander's Human Physiology
Vander's Human Physiology
15th Edition
ISBN: 9781259903885
Author: WIDMAIER, Eric P., Vander, Arthur J.
Publisher: Mcgraw-hill Education,
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Chapter 10, Problem 1GPA
Summary Introduction

To determine: The mechanism by which skeletal muscles are induced to contract.

Introduction: Skeletal muscle is one of the three types of muscles that are mostly under the voluntary control of the somatic nervous system. They are called so because skeletal muscles are attached to the bones or skeleton by collagen fibers called as tendons. In adults, about 40-50% of total body weight is contributed by skeletal muscles.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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