Concept explainers
Fill-in-the-Blank
The physical position of a gene on a chromosome is called its_______. Alternative forms of a gene are called __________. These alternative forms of genes arise as___________, which are changes in the
To review:
The given blank space in the statement, “The physical position of a gene on a chromosome is called _______. Alternative forms of a gene are called _______. These alternative forms of genes arise as ___________, which are changes in the nucleotide sequence of a gene.”
Introduction:
Gene is the biological unit of heredity. These are present on the chromosomes inside the nucleus in the eukaryotes. The DNA (deoxyribonucleic acid), in turn, is present in the genes. Genes are always present in two copies for a particular trait.
Explanation of Solution
A gene is made up of three DNA bases (example, AUG, TGG, GCG, ACT), which codes for a single amino acid. These triplet bases are present on the DNA and are known as codon when present on the mRNA (messenger ribonucleic acid). The place or spot where genes are present on the chromosomes is called locus. A locus marks the physical position of the gene on the chromosome.
The multiple forms of genes are known as alleles. They arise due to a mutation in the nucleotide sequence of the genes. These alleles are inherited from the parents, who contain either homozygous or heterozygous forms of these alleles. These alleles give variation to the newly formed organism as a result of reproduction. The changes in the sequence of the nucleotides or the replacement/removal of a base pair result in a mutation in the nucleotide sequence.
The physical position of a gene on a chromosome is called a locus. Alternative forms of a gene are called alleles. These alternative forms of genes arise as mutation, which are changes in the nucleotide sequence of a gene.
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Chapter 10 Solutions
Biology: Life on Earth
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- Being able to understand the relationship between DNA, mRNA, tRNA, ribosomes and proteins, is necessary for any researcher interested in gene therapy. Gene therapy is dedicated to correcting genetic defects by replacing mutated genes with wildtype versions. This can include complete removal and introduction of a working copy of the entire gene (using knock-outs and knock-ins) or removal of only the actual mutated nucleotide. Sickle Cell Disease is an example of a recessive disorder based on a single-point mutation: GAG becomes GTG, which encodes a new amino acid. One would only need to replace a single base to correct the disorder making it very attractive to gene therapy researchers. The mutant sickle cell allele is called HbS (for sickled hemoglobin) while the wt allele is HbA. Pretend that Arcel Kasongo, a masters student from Cambridge, is studying for an oral exam on gene therapy, and has an especial interest in the disorder since he comes from the Democratic Republic of Congo…arrow_forwardBeing able to understand the relationship between DNA, mRNA, tRNA, ribosomes and proteins, is necessary for any researcher interested in gene therapy. Gene therapy is dedicated to correcting genetic defects by replacing mutated genes with wildtype versions. This can include complete removal and introduction of a working copy of the entire gene (using knock-outs and knock-ins) or removal of only the actual mutated nucleotide. Sickle Cell Disease is an example of a recessive disorder based on a single-point mutation: GAG becomes GTG, which encodes a new amino acid. One would only need to replace a single base to correct the disorder making it very attractive to gene therapy researchers. The mutant sickle cell allele is called HbS (for sickled hemoglobin) while the wt allele is HbA. Pretend that Arcel Kasongo, a masters student from Cambridge, is studying for an oral exam on gene therapy, and has an especial interest in the disorder since he comes from the Democratic Republic of Congo…arrow_forwardExamine Figure . What type of chromosome (metacentric, submetacentric, acrocentric, or telocentric) is chromosome 1? What about chromosome 4?arrow_forward
- Genes with highly similar sequence are often located adjacent one another in the genome. Gene duplication commonly arises from errors in replication. When the organization of such adjacent genes is in an inverted orientation, this can reduce the expression of other genes that have similar sequence and are located on other chromosomes. Explain the mechanism of how this generally occurs. i need a detailed explanation, please. I need to know what the mechanism is. How it happens and why. Please. Thanksarrow_forwardWhich statement best describes a genomic library? an initial amount of DNA can be multiplied into millions of copies a large collection of bacteria that are engineered to contain fragments of an organism's complete genome a collection of DNA sequences are arranged on a microscopic grid many small pieces of circular, double-stranded DNA that replicate independently of chromosomes contained in a nucleusarrow_forwardexplain the statement Duplications Provide Extra Gene CopiesThat Can Acquire New Functionsarrow_forward
- State an industrial concern/importance for knowing the genetic makeup of an organism. Explain why it is important in your example.arrow_forwardPls see filearrow_forwardWhich of the following genetic alterations is most likely to result in a silent mutation? a transversion mutation a duplication of one chromosome a frameshift mutation a deletion of one chromosome a transition mutationarrow_forward
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