Chapter 10, Problem 10.54SP

(a)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{CHDOH}$ using ${\text{LiAlD}}_{\text{4}}$ or ${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{CHDOH}$ using ${\text{LiAlD}}_{\text{4}}$ or ${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. Deuterium is introduced by using reagent ${\text{LiAlD}}_{\text{4}}$ which is equivalent to ${\text{LiAlH}}_{\text{4}}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.

(b)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}{\text{CD}}_2\text{OH}$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}{\text{CD}}_2\text{OH}$ using ${\text{LiAlD}}_{\text{4}}$,${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. The deuterium is introduced by using reagent ${\text{LiAlD}}_{\text{4}}$ which is equivalent to ${\text{LiAlH}}_{\text{4}}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.

(c)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}{\text{CD}}_2\text{OD}$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}{\text{CD}}_2\text{OD}$ using ${\text{LiAlD}}_{\text{4}}$,${\text{D}}_{\text{2}}\text{O}$ and any non-deuterated starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. The deuterium is introduced by using reagent ${\text{LiAlD}}_{\text{4}}$ which is equivalent to ${\text{LiAlH}}_{\text{4}}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.