CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
3rd Edition
ISBN: 9780134875040
Author: Urry
Publisher: PEARSON
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Chapter 1, Problem 9TYU
FOCUS ON EVOLUTION
In a short essay (100-150), describe Darwin’s view of how natural section resulted in both unity and diversity of life on Earth Include in your discussion some his evidence (See tips, for writing good essays and suggested grading rubric in the Study Area of Mastering Biology under “Writing Tips and Rubric”)
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 1 Solutions
CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
Ch. 1.1 - Starting with the molecular level in Figure 1.3,...Ch. 1.1 - Identify me theme or themes exemplified by (a) the...Ch. 1.1 - WHAT IF? For each theme discussed in this section...Ch. 1.2 - How is a mailing address analogous to biologys...Ch. 1.2 - Explain why editing is an appropriate metaphor for...Ch. 1.2 - DRAW IT Recent evidence indicates that fungi and...Ch. 1.3 - Contrast inductive reasoning with deductive...Ch. 1.3 - What qualitative observation led to the...Ch. 1.3 - Why is natural selection called a theory?Ch. 1.3 - How does science differ from technology?
Ch. 1 - All the organisms on your campus make up A. an...Ch. 1 - Which of the following best demonstrates the unity...Ch. 1 - Prob. 3TYUCh. 1 - Prob. 4TYUCh. 1 - Which of the following best describes the logic of...Ch. 1 - DRAW IT With rough sketches, draw a biological...Ch. 1 - SCIENTIFIC INQUIRY Based on the results of the...Ch. 1 - Prob. 8TYUCh. 1 - FOCUS ON EVOLUTION In a short essay (100-150),...Ch. 1 - FOCUS ON INFORMATION A typical prokaryotic cell...Ch. 1 - SYNTHESI7F YOUR KNOWLEDGE Can you pick out the...
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