EBK GENETICS: FROM GENES TO GENOMES
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 1, Problem 6P

RNA shares with proteins the ability to fold into complex three-dimensional shapes. As a result, RNA molecules can, like protein molecules, catalyze biochemical reactions (that is, both kinds of molecules can act as enzymes, or biological catalysts). These statements are not true of DNA. Why can some RNA molecules act as enzymes whereas DNA molecules cannot? (Hint: Most RNA molecules consist of a single strand of nucleotides while most DNA molecules are double helixes made of two strands of nucleotides.)

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The metabolic pathway below is used for the production of the purine nucleotides adenosine monophosphate (AMP) and guanosine monophosphate (GMP) in eukaryotic cells. Assume each arrow represents a reaction catalyzed by a different enzyme. Using the principles of feedback inhibition, propose a regulatory scheme for this pathway that ensures an adequate supply of both AMP and GMP, and prevents the buildup of Intermediates A through G when supplies of both AMP and GMP are adequate.
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