HUMAN ANAT&PHYS&MOD MA&P/ET&PHOTO ATLAS
2nd Edition
ISBN: 9780135170717
Author: AMERMAN
Publisher: PEARSON
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Chapter 1, Problem 4CYR
Summary Introduction
Introduction:
The human body consists of six levels of structural organization thatcomprise the building blocks of the body. All these levels when combined with each other, form an organism.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 1 Solutions
HUMAN ANAT&PHYS&MOD MA&P/ET&PHOTO ATLAS
Ch. 1.1 - What are some examples of learning modalities?Ch. 1.1 - 2. How should you approach reading a textbook,...Ch. 1.1 - What are some study strategies to improve your...Ch. 1.1 - Prob. 4QCCh. 1.1 - 5. What are some strategies for taking good notes...Ch. 1.1 - 6. How can you use the features found in each...Ch. 1.1 - 7. How should you approach the study of figures...Ch. 1.2 - What are the properties common to all living...Ch. 1.2 - Prob. 2QCCh. 1.2 - 3. What are the 11 organ systems in the body?
Ch. 1.2 - 4. How do gross anatomy and microscopic anatomy...Ch. 1.2 - How are physiological specializations classified?Ch. 1.3 - What is anatomical position?Ch. 1.3 - Fill in the blanks: The nose is to the mouth....Ch. 1.3 - Fill in the blanks: a. The wrist is also known as...Ch. 1.3 - How do the three main planes of section differ?Ch. 1.4 - What are the two subcavities of the posterior body...Ch. 1.4 - 2. List the subdivisions of the thoracic and...Ch. 1.4 - 3. What are serous membranes, and what are their...Ch. 1.4 - Explain how serous membranes form certain anterior...Ch. 1.5 - 1. What is homeostasis, and why is it important?
Ch. 1.5 - 2. What is a homeostatic imbalance?
Ch. 1.5 - How do negative feedback loops maintain...Ch. 1.5 - Prob. 4QCCh. 1.5 - Prob. 5QCCh. 1.5 - What is a gradient? What are some examples of...Ch. 1.5 - 7. Why is cell-cell communication important?
Ch. 1.5 - 8. What are the two major methods by which cells...Ch. 1 - Fill in the blanks: The study of the form of the...Ch. 1 - Mark the following statements as true or false. If...Ch. 1 - Prob. 3CYRCh. 1 - Prob. 4CYRCh. 1 - 5. Which of the following correctly describes the...Ch. 1 - Mark the following statements as true or false. If...Ch. 1 - Match the following terms with the correct...Ch. 1 - 8. The upper and lower limbs are known broadly as...Ch. 1 - The arm is known as the ___________ region; the...Ch. 1 - A parasagittal section divides the body or body...Ch. 1 - 11. Fill in the blanks: The two divisions of the...Ch. 1 - 12. Fill in the blanks: The two main divisions of...Ch. 1 - 13. In which of the following cavities do serous...Ch. 1 - 14. Serous fluid functions in:
a. Providing...Ch. 1 - 15. Which organs would you expect to find in the...Ch. 1 - 16. Mark the following statements as true or...Ch. 1 - Prob. 17CYRCh. 1 - Examine the structure of the skull, and predict...Ch. 1 - Prob. 2CYUCh. 1 - Prob. 1AYKCh. 1 - 2. During a procedure on Ms. Norman’s pancreas, a...Ch. 1 - Later that same day, the surgeon performs a...Ch. 1 - The baroreceptor reflex causes blood pressure to...
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