The factors that probably stimulated an early interest in the human body. Introduction: Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

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Answer 1

Question

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

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Answer 2

Question

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

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Answer 3

Question

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

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Answer 4

Question

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

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Answer 5

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

Answer 6

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

Answer 7

Chapter 1, Problem 1P

Summary Introduction

To determine:

The factors that probably stimulated an early interest in the human body.

Introduction:

Understanding the human body has an interesting and long history. The ancestors would have been very curious about studying the mechanisms of the human body and so, they must have wondered how the body fights against various illnesses.

Answer 8

Expert Solution & Answer

Explanation of Solution

A healthy body does not require much attention or demand special care. However, an injured body demands more attention. The suffering from pains and aches, whenever people were injured, broken bones, contracted infections, bled and developed diseases, they triggered the people to think about their causes.

Initially, the healers heavily relied on superstitions and magic to heal sick people. It was much later that medical workers started treating the ill and examining the human body with medical techniques. Hence, they first observed the effects of injuries and illnesses, then they noticed how the wounds heal and lastly, they examined the dead bodies of humans to determine the cause of death.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Conclusion

The factors that had probably stimulated an early interest in the human body were illnesses and injuries suffered by primitive people, which led to the discovery of medical treatments.

Answer 12

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