Modified Mastering Microbiology wit
6th Edition
ISBN: 9780135174739
Author: BAUMAN
Publisher: PEARSON
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Textbook Question
Chapter 1, Problem 1CT
If Robert Koch had become interested in a viral disease, such as influenza, instead of anthrax (caused by a bacterium), how might his list of lifetime accomplishments be different? Why?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
Modified Mastering Microbiology wit
Ch. 1 - What does the science of microbiology study?Ch. 1 - Are most microorganisms harmful or harmless to...Ch. 1 - Patty is a mother to 14-year-old twins and works...Ch. 1 - What scientific device did van Leeuwenhoek create?Ch. 1 - Prob. 2MICCh. 1 - Van Leeuwenhoek described bacteria, archaea,...Ch. 1 - All eukaryotic cells contain most of their genetic...Ch. 1 - What term describes the idea that living organisms...Ch. 1 - The investigations of which researcher finally...Ch. 1 - Today we understand that yeasts and bacteria can...
Ch. 1 - What industry has the work of Pasteur most...Ch. 1 - Which researcher ultimately gave us a method for...Ch. 1 - Which researcher developed the staining technique...Ch. 1 - Prob. 11MICCh. 1 - The use of antiseptic chemicals during surgical...Ch. 1 - Prob. 13MICCh. 1 - Some people consider Leeuwenhoek the Father of...Ch. 1 - Why might Nightingale be considered the Mother of...Ch. 1 - Prob. 3TMWCh. 1 - In the late 18th century, Philadelphia was one of...Ch. 1 - Emerging Disease Case Study Variant...Ch. 1 - Prob. 1MCFUCh. 1 - Dr. Andrews has a lot of questions tot Patty. When...Ch. 1 - Which of the following microorganisms are not...Ch. 1 - Prob. 2MCCh. 1 - In which habitat would you most likely find...Ch. 1 - Of the following scientists, who first promulgated...Ch. 1 - Which of the following scientists hypothesized...Ch. 1 - Prob. 6MCCh. 1 - Prob. 7MCCh. 1 - Prob. 8MCCh. 1 - Prob. 9MCCh. 1 - The laboratory of Robert Koch contributed which of...Ch. 1 - Prob. 1FIBCh. 1 - Prob. 2FIBCh. 1 - Chemotherapy _______________Ch. 1 - Prob. 4FIBCh. 1 - Infection control _______________Ch. 1 - Prob. 6FIBCh. 1 - Epidemiology _______________Ch. 1 - Biotechnology _______________Ch. 1 - Prob. 9FIBCh. 1 - Why was the theory of spontaneous generation a...Ch. 1 - Discuss the significant difference between the...Ch. 1 - List six types of microorganisms.Ch. 1 - Defend this statement: The investigations of...Ch. 1 - Why would a macroscopic tapeworm be studied in...Ch. 1 - Describe what has been called the Golden Age of...Ch. 1 - List four major questions that drive...Ch. 1 - Prob. 8SACh. 1 - Prob. 9SACh. 1 - What does the term HAI (nosocomial infection) have...Ch. 1 - Match each of the following descriptions with the...Ch. 1 - Prob. 1VICh. 1 - Prob. 2VICh. 1 - If Robert Koch had become interested in a viral...Ch. 1 - In 1911, the Polish scientist Casimir Funk...Ch. 1 - Haemophilus influenzae does not cause flu, but it...Ch. 1 - Just before winter break in early December, your...Ch. 1 - Design an experiment to prove that microbes do not...Ch. 1 - Prob. 6CTCh. 1 - Compare and contrast the investigations of Redi,...Ch. 1 - If you were a career counselor directing a student...Ch. 1 - A few bacteria produce disease because they derive...Ch. 1 - How might the debate over spontaneous generation...Ch. 1 - French microbiologists, led by Pasteur, tried to...Ch. 1 - Why arent Kochs postulates always useful in...Ch. 1 - Albert Kluyver said, From elephant to ......Ch. 1 - The ability of farmers around the world to produce...Ch. 1 - Prob. 15CTCh. 1 - Using the following terms, fill in the following...
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