Connect with LearnSmart Labs Access Card for Seeley's A&P
11th Edition
ISBN: 9781259807657
Author: Cinnamon VanPutte, Jennifer Regan, Andrew F. Russo Dr., Rod R. Seeley Dr.
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 1, Problem 19RAC
Which of the following organs are not retroperitoneal?
a. adrenal glands c. kidneys e. stomach
b. urinary bladder d. pancreas
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
Connect with LearnSmart Labs Access Card for Seeley's A&P
Ch. 1.1 - How does the study of anatomy differ from the...Ch. 1.1 - What is studied in gross anatomy? In surface...Ch. 1.1 - Prob. 3AYPCh. 1.1 - Why are anatomy and physiology normally studied...Ch. 1.2 - From simplest to complex, list and define the...Ch. 1.2 - What are the four basic types of tissues?Ch. 1.2 - Referring to figure 1.3, which two organ systems...Ch. 1.3 - What are the six characteristics of living things?...Ch. 1.3 - How does differentiation differ from...Ch. 1.4 - Prob. 10AYP
Ch. 1.4 - How do variables, set points, and normal ranges...Ch. 1.4 - Prob. 12AYPCh. 1.4 - Prob. 13AYPCh. 1.4 - Give an example of how a negative-feedback...Ch. 1.4 - Prob. 15AYPCh. 1.6 - What is anatomical position in humans? Why is it...Ch. 1.6 - What two directional terms indicate “toward the...Ch. 1.6 - What two directional terms indicate “the bock” in...Ch. 1.6 - Define the following directional terms and give...Ch. 1.6 - What makes up the central region of the body?Ch. 1.6 - What is the difference between the arm and the...Ch. 1.6 - What are the anatomical terms for the following...Ch. 1.6 - In what quadrant would the majority of the stomach...Ch. 1.6 - List and describe the three planes of the body.Ch. 1.6 - In what three ways can you cut an organ?Ch. 1.6 - What structure separates the thoracic cavity from...Ch. 1.6 - What structure divides the thoracic cavity into...Ch. 1.6 - What is a serous membrane and its function?...Ch. 1.6 - Prob. 29AYPCh. 1.6 - What are mesenteries? Explain their function.Ch. 1.6 - What are retroperitoneal organs? List five...Ch. 1 - Physiology a. deals with the processes or...Ch. 1 - The following are organizational levels for...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - The characteristic of life that is defined as “all...Ch. 1 - The following events are part of a...Ch. 1 - Which of these statements concerning positive...Ch. 1 - A term that means nearer the attached end of a...Ch. 1 - Which of these directional terms are paired most...Ch. 1 - The part of the upper limb between the elbow and...Ch. 1 - A patient with appendicitis usually has pain in...Ch. 1 - A plane that divides the body into anterior and...Ch. 1 - The lungs are Part of the mediastinum. Surrounded...Ch. 1 - Given the following organ and cavity combinations:...Ch. 1 - Which if the following membrane combination are...Ch. 1 - Which of the following organs are not...Ch. 1 - Prob. 1CTCh. 1 - A male has lost blood as a result of a gunshot...Ch. 1 - Provide the correct directional term for the...Ch. 1 - During pregnancy, which of the mother’s body...Ch. 1 - A woman falls while skiing and is accidentally...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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