Laboratory Manual for Human Anatomy
5th Edition
ISBN: 9781259683831
Author: Eric Wise, Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 1, Problem 1.3.3AYLO
To test your knowledge, discuss the following topics with a study partner or in writing. Ideally from memory.
3. How to divide medical terms such as histology, cardiovascular, anatomy, endometrium, pseudostratified, subcutaneous, corticospinal, and hypodermic into their prefiexe, roots. Combining forms, and suffixes, and how to recognize combining vowels where they exist
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
Laboratory Manual for Human Anatomy
Ch. 1.1 - The concept of MRI was conceived in 1948 but could...Ch. 1.1 - Prob. 2AWYKCh. 1.1 - Answer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.2 - Anwer the following questions to test your...Ch. 1.2 - Anwer the following questions to test your...Ch. 1.2 - Prob. 7BYGOCh. 1.2 - Prob. 8BYGO
Ch. 1.2 - Prob. 9BYGOCh. 1.3 - Anwer the following questions to test your...Ch. 1.3 - Anwer the following questions to test your...Ch. 1.3 - Prob. 12BYGOCh. 1.3 - Prob. 13BYGOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.1.2AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.2AYLOCh. 1 - Prob. 1.2.3AYLOCh. 1 - Prob. 1.2.4AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.6AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.9AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.11AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.13AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.16AYLOCh. 1 - Prob. 1.2.17AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.3.2AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.3.4AYLOCh. 1 - Prob. 1.3.5AYLOCh. 1 - Prob. 1.3.6AYLOCh. 1 - Prob. 1.3.7AYLOCh. 1 - Structure that can be observed with the naked eye...Ch. 1 - Prob. 2TYRCh. 1 - Prob. 3TYRCh. 1 - Prob. 4TYRCh. 1 - Prob. 5TYRCh. 1 - Which of these regions is not part of the upper...Ch. 1 - Prob. 7TYRCh. 1 - Which of these is not an organ sytem? muscular...Ch. 1 - Prob. 9TYRCh. 1 - An imaging technique that exposes the patient to...Ch. 1 - Prob. 11TYRCh. 1 - The forearm is said to be ________ when the palms...Ch. 1 - Prob. 13TYRCh. 1 - Prob. 14TYRCh. 1 - Prob. 15TYRCh. 1 - Prob. 16TYRCh. 1 - Prob. 17TYRCh. 1 - Prob. 18TYRCh. 1 - Prob. 19TYRCh. 1 - Prob. 20TYRCh. 1 - Prob. 1BYMVCh. 1 - State a meaning of each word element and give a...Ch. 1 - Prob. 3BYMVCh. 1 - Prob. 4BYMVCh. 1 - Prob. 5BYMVCh. 1 - Prob. 6BYMVCh. 1 - Prob. 7BYMVCh. 1 - Prob. 8BYMVCh. 1 - Prob. 9BYMVCh. 1 - Prob. 10BYMVCh. 1 - Determine which five of the following statements...Ch. 1 - Prob. 2TOFCh. 1 - Briefly explain why each of the following...Ch. 1 - Prob. 4TOFCh. 1 - Prob. 5TOFCh. 1 - Prob. 6TOFCh. 1 - Briefly explain why each of the following...Ch. 1 - Prob. 8TOFCh. 1 - Prob. 9TOFCh. 1 - Prob. 10TOFCh. 1 - Classify each of the following radiologic...Ch. 1 - Prob. 2TYCCh. 1 - Prob. 3TYCCh. 1 - Prob. 4TYCCh. 1 - Why do you think the writers of Terminologia...
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