You are testing a compound as cardioactive drug.You know the compound is an agonist ofacetylcholine (ACh) at the relevant ACh receptor(AChR) on sinoatrial (SA) node cells. Brieflydescribe how the action of the drug likely wouldaffect the electrical signal produced by the SAnode cells. In respect of cardiac output, whatwould you expect to be the effect of this drug?

The sinoatrial (SA) node is known as the natural pacemaker of the heart, responsible for generating…

Answered: You are testing a compound as…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Which of the following combinations would have OPPOSITE effects in changing heart rate? atropine and norepinephrine atropine and a cholinesterase inhibitor epinephrine and norepinephrine acetylcholine and a cholinesterase inhibitor
A 28-year-old athlete is noted to have a baseline heart rate of 55bpm, which his trainer attributes to excellent parasympathetic (vagal) tone. This parasympathetic effect normally increases Ach release at the SA and AV nodes. Ach release into AV node leads to which of the following effects of its fibers? a. increased action potential amplitudeb. increased conduction velocityc. increased K+ equilibrium potentiald. Hyperpolarizatione. increased rate of depolarization of the pacemaker potential
Using information provided in the text, calculate the power generated by the right ventricle during (a) restful state; blood flow 5 liter/min, and (b) intense activity; blood flow 25 liter/min.
For cardiac muscle action potentials, describe ionmovement during the depolarization, early repolarization,plateau, and final repolarization phases.
Cells of the sinoatrial node are the primary pacemakers of the heart. If we increase the potassium ions permeability of these cells, how many action potentials do these cells generate every minute?
Fill in the following blanks (a - f) regarding the Baroreceptor Reflex Control: The baroreceptor reflex control is a negative feedback loop. If the patient is hypotensive, they are experiencing a decrease in blood pressure detected by (a.)_ located in the aortic and carotid bodies. The afferent pathways include the (b.)_ nerve and the (c.)__ nerve. These synapse at the cardioregulatory and vasomotor integration centers located in the (d.)_ These centers will cause the heart rate to (e.)(increase/decrease) and blood vessels to (f.) (vasodilate/vasocontrict). For the toolbar press ALT+510 (BC) or ALTHEN±+510/Mad
Decreasing blood pressure to the Aortic Arch & Carotid Sinuses should reflexly: decrease heart rate & increase stroke volume increase vascular resistance & decrease heart rate decrease stroke volume & decrease vascular resistance A. B. C. D. increase cardiac output & increase vascular resistance Using the Baro-receptor feedback mechanism, the parasysmpathetic nervous system can affect which of the following variables to adjust blood pressure? A. heart rate stroke volume vascular resistance B. C. D. contractility An individual possessing only the A & B antigens is said to be of which blo fype? A. A+ В. AB+ С. AB- D.
Choose the receptor(s) that mediate the following response: Positive inotropic effect on the heart Select one: β1 α2 β2 α1
The next patient seen by the same doctor was suffering from hyperkalemia and was experiencing cardiac arrhythmias. Which of the following reason/s explain/s why this patient was experiencing cardiac arrhythmias? O hyperkalemia leads to an increase in action potential generation because potassium ions in the ECF makes the resting membrane potential more negative O hyperkalemia leads to a decrease in action potential generation because the potassium ion level in the ICF will cause hyperpolarization O hyperkalemia leads to an increase in action potential generation because the high level of potassium ions in the ICF will make achieving threshold easier O a and b
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Using Figure 4 as a reference, explain whether there was a difference in the resting heart rates of athletes and non-athletes. Explain the physiology behind your results in terms of the relationship between heart rate and stroke volume
A drug that blocks the cardiac muscarinic receptor might be expected to: Increased heart rate Decreased heart rate Open mechanically-gated K channels Decreased contractility Decrease pacemaker potential

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