You are testing a compound as cardioactive drug.You know the compound is an agonist ofacetylcholine (ACh) at the relevant ACh receptor(AChR) on sinoatrial (SA) node cells. Brieflydescribe how the action of the drug likely wouldaffect the electrical signal produced by the SAnode cells. In respect of cardiac output, whatwould you expect to be the effect of this drug?

The sinoatrial (SA) node is known as the natural pacemaker of the heart, responsible for generating…

Answered: You are testing a compound as…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Which of the following combinations would have OPPOSITE effects in changing heart rate? atropine and norepinephrine atropine and a cholinesterase inhibitor epinephrine and norepinephrine acetylcholine and a cholinesterase inhibitor
Which of the following statements best describes the differences in the regulation of cardiac and skeletal muscle contraction? The amount of contractile force actively generated by muscle cells is increased by stretch in skeletal muscle and decreased by stretch in cardiac muscle. Cardiac muscle is stimulated by motor neurons and skeletal muscle by neurones from the autonomic nervous system. Skeletal muscle contractile force is augmented by increasing the firing frequency of action potentials whereas cardiac muscle contractile force is enhanced by noradrenaline increasing calcium influx through ion channels. Ryanodine receptors in skeletal muscle are opened by a mechanism that requires calcium influx whereas in cardiac muscle membrane depolarisation alone without calcium influx is sufficient to open ryanodine receptors.
Fill in the following blanks (a - f) regarding the Baroreceptor Reflex Control: The baroreceptor reflex control is a negative feedback loop. If the patient is hypotensive, they are experiencing a decrease in blood pressure detected by (a.)_ located in the aortic and carotid bodies. The afferent pathways include the (b.)_ nerve and the (c.)__ nerve. These synapse at the cardioregulatory and vasomotor integration centers located in the (d.)_ These centers will cause the heart rate to (e.)(increase/decrease) and blood vessels to (f.) (vasodilate/vasocontrict). For the toolbar press ALT+510 (BC) or ALTHEN±+510/Mad
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The next patient seen by the same doctor was suffering from hyperkalemia and was experiencing cardiac arrhythmias. Which of the following reason/s explain/s why this patient was experiencing cardiac arrhythmias? O hyperkalemia leads to an increase in action potential generation because potassium ions in the ECF makes the resting membrane potential more negative O hyperkalemia leads to a decrease in action potential generation because the potassium ion level in the ICF will cause hyperpolarization O hyperkalemia leads to an increase in action potential generation because the high level of potassium ions in the ICF will make achieving threshold easier O a and b
Roberto is a 78-year-old male who has recently been diagnosed with Class III Congestive Heart Failure (CHF). His physician told him that his left ventricle has become stiff and cannot relax. Although there is no current treatment that can “fix” Roberto’s condition, he is prescribed two medications: an ACE inhibitor and beta blockers.Briefly describe how beta-blockers will influence Roberto’s heart function, specifically the physiology of the ventricles.
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Sue goes to the gym and after an initial warm-up, she increases her exercise level pushing herself to maximum. At this point her heart rate is 175 beats/min and her stroke volume is 135 ml/beat. What is her cardiac output now? At this point, by how many ml/min has her CO increased over her resting CO? What % increase over resting is this? (Use the following equation). amount of increase in CO in ml/min % increase = _____________ X 100% original CO (resting) ml/min What term is used to describe this increase in CO?

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